Relationships between metabolic status, seminal adipokines, and reproductive functions in men from infertile couples

Objective Adipokines could be a link between metabolic syndrome (MS) and infertility. While the association between circulating adipokines and fertility has been extensively studied in females, this relationship in males was less investigated, although some adipokines are detectable in seminal plasm...

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Published in:European journal of endocrinology 2020-01, Vol.182 (1), p.67-77
Main Authors: Elfassy, Yaelle, Bongrani, Alice, Levy, Pierre, Foissac, Frantz, Fellahi, Soraya, Faure, Céline, McAvoy, Chloé, Capeau, Jacqueline, Dupont, Joëlle, Fève, Bruno, Levy, Rachel, Bastard, Jean-Philippe
Format: Article
Language:English
Subjects:
Adipokines - blood
Adipokines - metabolism
Adiponectin
Adolescent
Adult
Chemokines - blood
Chemokines - metabolism
Clinical Study
Couples
Female
Humans
Infertility
Infertility, Male - metabolism
Infertility, Male - physiopathology
Interleukin 6
Interleukin-6 - blood
Interleukin-6 - metabolism
Leptin
Leptin - blood
Leptin - metabolism
Life Sciences
Male
Metabolic syndrome
Metabolism
Middle Aged
Nicotinamide Phosphoribosyltransferase - blood
Nicotinamide Phosphoribosyltransferase - metabolism
Reproduction - physiology
Reproductive Biology
Semen
Semen - metabolism
Semen - physiology
Sperm
Sperm Count
Sperm Motility - physiology
Spermatozoa - metabolism
Spermatozoa - physiology
Young Adult
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Summary:Objective Adipokines could be a link between metabolic syndrome (MS) and infertility. While the association between circulating adipokines and fertility has been extensively studied in females, this relationship in males was less investigated, although some adipokines are detectable in seminal plasma (SP). The aim of this study was to determine adipokine levels in blood and SP and to assess the relationships between adipokines, MS and semen parameters in men from infertile couples. Design Male partners of infertile couples referred to four medical French centers were enrolled in years 2013–2016. Methods Subjects (n = 160) aged 18–45 years were assessed for anthropometric, biochemical, sperm, and circulating hormonal parameters. Leptin, adiponectin, resistin, chemerin, visfatin, and IL-6 were measured in serum and SP. Results Infertility duration was higher in men with than without MS. Adipokine concentrations were higher in blood than in SP, except for IL-6 and visfatin. The most striking result was the significant correlation observed between seminal IL-6 and spermatozoid concentration, progressive motility, and sperm vitality. Moreover, while men with MS exhibited an expected lower adiponectinemia, they displayed 2.1-fold higher adiponectin levels in SP than men without MS. Finally, logistic regression analysis showed that BMI, infertility duration, and adiponectin serum/SP ratio were independently associated with MS. Conclusions These results suggest an involvement of seminal adipokines to modulate fertility in men with MS and that seminal IL-6 could play a beneficial role on sperm functionality. Further mechanistic studies are necessary to investigate the precise roles of these adipokines in male reproduction.
ISSN:0804-4643
1479-683X
DOI:10.1530/EJE-19-0615