Relationship between renal capacity to reabsorb glucose and renal status in patients with diabetes

•Susceptibility to kidney disease is heterogenous in patients with diabetes.•We assessed fractional renal glucose reabsorption in patients with diabetes.•Glucose reabsorption capacity and renal status severity were strongly associated.•High renal glucose reabsorption might contribute to diabetic kid...

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Bibliographic Details
Published in:Diabetes & metabolism 2020-11, Vol.46 (6), p.488-495
Main Authors: Matar, O., Potier, L., Abouleka, Y., Hallot-Feron, M., Fumeron, F., Mohammedi, K., Hadjadj, S., Roussel, R., Velho, G., Marre, M.
Format: Article
Language:English
Subjects:
Diabetic kidney disease
Life Sciences
Renal glucose transport
Tubuloglomerular feedback
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Summary:•Susceptibility to kidney disease is heterogenous in patients with diabetes.•We assessed fractional renal glucose reabsorption in patients with diabetes.•Glucose reabsorption capacity and renal status severity were strongly associated.•High renal glucose reabsorption might contribute to diabetic kidney disease. Interindividual variability in capacity to reabsorb glucose at the proximal renal tubule could contribute to risk of diabetic kidney disease. Our present study investigated, in patients with diabetes, the association between fractional reabsorption of glucose (FRGLU) and degree of renal disease as assessed by urinary albumin excretion (UAE) and estimated glomerular filtration rate (eGFR). FRGLU [1-(glucose clearance/creatinine clearance)] was assessed in 637 diabetes patients attending our tertiary referral centre, looking for correlations between FRGLU and UAE (normo-, micro-, macro-albuminuria) and Kidney Disease: Improving Global Outcomes (KDIGO) eGFR categories: >90 (G1); 90–60 (G2); 59–30 (G3); and
ISSN:1262-3636
1878-1780
DOI:10.1016/j.diabet.2020.03.002