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Microcracks in subchondral bone plate is linked to less cartilage damage
Osteoarthritis (OA) is a disease of the whole joint characterized by cartilage loss and subchondral bone remodeling. The role of microcracks in cartilage integrity and subchondral bone homeostasis is not fully understood. The main goal of this work was to evaluate microcrack density in both calcifie...
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| Published in: | Bone (New York, N.Y.) N.Y.), 2019-06, Vol.123, p.1-7 |
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| cites | cdi_FETCH-LOGICAL-c434t-2ad729006ad65e3ba8b32e1861fb2de524f65d43b7654078acedb62652b1d9703 |
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| container_title | Bone (New York, N.Y.) |
| container_volume | 123 |
| creator | Zarka, M. Hay, E. Ostertag, A. Marty, C. Chappard, C. Oudet, F. Engelke, K. Laredo, J.D. Cohen-Solal, M. |
| description | Osteoarthritis (OA) is a disease of the whole joint characterized by cartilage loss and subchondral bone remodeling. The role of microcracks in cartilage integrity and subchondral bone homeostasis is not fully understood. The main goal of this work was to evaluate microcrack density in both calcified cartilage and subchondral bone plate in relation to cartilage damage in humans and to better define the association of microcracks and osteocyte density in subchondral bone.
We investigated 18 bone cores from cadaveric human knees that were stained with En-Bloc Basic Fuchsin. We quantified microcrack density, osteocyte density, cartilage surfaces and cartilage damage. The presence of microcracks was confirmed for each bone core by scanning electron microscopy. Finally, trabecular subchondral bone parameters were measured by micro-CT.
Microcracks were detected in both calcified cartilage and subchondral bone plate. The density of microcracks in both calcified cartilage (CC) and subchondral bone plate (SBP) was negatively correlated with cartilage damage (r = −0.45, p |
| doi_str_mv | 10.1016/j.bone.2019.03.011 |
| format | article |
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We investigated 18 bone cores from cadaveric human knees that were stained with En-Bloc Basic Fuchsin. We quantified microcrack density, osteocyte density, cartilage surfaces and cartilage damage. The presence of microcracks was confirmed for each bone core by scanning electron microscopy. Finally, trabecular subchondral bone parameters were measured by micro-CT.
Microcracks were detected in both calcified cartilage and subchondral bone plate. The density of microcracks in both calcified cartilage (CC) and subchondral bone plate (SBP) was negatively correlated with cartilage damage (r = −0.45, p < 0.05). The presence of microcracks in SBP was associated with a lower histological OA score. Osteocytes formed a dendrite network that abruptly stopped at the border of calcified cartilage. Osteocyte density in subchondral bone plate was increased in the presence of microcracks in calcified cartilage.
Subchondral bone plate microcracks might be required for maintaining cartilage homeostasis. Microcracks in calcified cartilage may trigger osteocyte density in subchondral bone plate with subsequent regulation of subchondral bone remodeling to prevent cartilage damage.
•Subchondral bone contains a high density of osteocytes, the dendrites of which are bordering the calcified cartilage•Microcracks are negatively correlated with cartilage damage, suggesting that they might be required for cartilage homeostasis•Microcracks in the calcified cartilage are associated with increased osteocyte density in the subchondral bone•Microcracks in the calcified cartilage might regulate subchondral bone remodeling</description><identifier>ISSN: 8756-3282</identifier><identifier>EISSN: 1873-2763</identifier><identifier>EISSN: 8756-3282</identifier><identifier>DOI: 10.1016/j.bone.2019.03.011</identifier><identifier>PMID: 30862540</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Bone ; Life Sciences ; Mechanical loading ; Microcracks ; Osteoarthritis ; Osteocytes</subject><ispartof>Bone (New York, N.Y.), 2019-06, Vol.123, p.1-7</ispartof><rights>2019 Elsevier Inc.</rights><rights>Copyright © 2019 Elsevier Inc. All rights reserved.</rights><rights>Attribution - NonCommercial</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c434t-2ad729006ad65e3ba8b32e1861fb2de524f65d43b7654078acedb62652b1d9703</citedby><cites>FETCH-LOGICAL-c434t-2ad729006ad65e3ba8b32e1861fb2de524f65d43b7654078acedb62652b1d9703</cites><orcidid>0000-0003-3179-4432 ; 0000-0001-9875-4123</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,315,786,790,891,27957,27958</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30862540$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.science/hal-03485638$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Zarka, M.</creatorcontrib><creatorcontrib>Hay, E.</creatorcontrib><creatorcontrib>Ostertag, A.</creatorcontrib><creatorcontrib>Marty, C.</creatorcontrib><creatorcontrib>Chappard, C.</creatorcontrib><creatorcontrib>Oudet, F.</creatorcontrib><creatorcontrib>Engelke, K.</creatorcontrib><creatorcontrib>Laredo, J.D.</creatorcontrib><creatorcontrib>Cohen-Solal, M.</creatorcontrib><title>Microcracks in subchondral bone plate is linked to less cartilage damage</title><title>Bone (New York, N.Y.)</title><addtitle>Bone</addtitle><description>Osteoarthritis (OA) is a disease of the whole joint characterized by cartilage loss and subchondral bone remodeling. The role of microcracks in cartilage integrity and subchondral bone homeostasis is not fully understood. The main goal of this work was to evaluate microcrack density in both calcified cartilage and subchondral bone plate in relation to cartilage damage in humans and to better define the association of microcracks and osteocyte density in subchondral bone.
We investigated 18 bone cores from cadaveric human knees that were stained with En-Bloc Basic Fuchsin. We quantified microcrack density, osteocyte density, cartilage surfaces and cartilage damage. The presence of microcracks was confirmed for each bone core by scanning electron microscopy. Finally, trabecular subchondral bone parameters were measured by micro-CT.
Microcracks were detected in both calcified cartilage and subchondral bone plate. The density of microcracks in both calcified cartilage (CC) and subchondral bone plate (SBP) was negatively correlated with cartilage damage (r = −0.45, p < 0.05). The presence of microcracks in SBP was associated with a lower histological OA score. Osteocytes formed a dendrite network that abruptly stopped at the border of calcified cartilage. Osteocyte density in subchondral bone plate was increased in the presence of microcracks in calcified cartilage.
Subchondral bone plate microcracks might be required for maintaining cartilage homeostasis. Microcracks in calcified cartilage may trigger osteocyte density in subchondral bone plate with subsequent regulation of subchondral bone remodeling to prevent cartilage damage.
•Subchondral bone contains a high density of osteocytes, the dendrites of which are bordering the calcified cartilage•Microcracks are negatively correlated with cartilage damage, suggesting that they might be required for cartilage homeostasis•Microcracks in the calcified cartilage are associated with increased osteocyte density in the subchondral bone•Microcracks in the calcified cartilage might regulate subchondral bone remodeling</description><subject>Bone</subject><subject>Life Sciences</subject><subject>Mechanical loading</subject><subject>Microcracks</subject><subject>Osteoarthritis</subject><subject>Osteocytes</subject><issn>8756-3282</issn><issn>1873-2763</issn><issn>8756-3282</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNp9kE1v1DAQQC0EotvCH-CAfIRDwthObEfiUlWlW2krLnC2_DFLvfUmi52txL_H0bY99jSS9ebZfoR8YtAyYPLbrnXTiC0HNrQgWmDsDVkxrUTDlRRvyUqrXjaCa35GzkvZAYAYFHtPzgRoyfsOVmR9F32efLb-odA40nJ0_n4aQ7aJLnZ6SHZGGgtNcXzAQOeJJiyFepvnmOwfpMHu6_hA3m1tKvjxaV6Q3z-uf12tm83Pm9ury03jO9HNDbdB8QFA2iB7FM5qJzgyLdnW8YA977ayD51wStb3KW09Bie57LljYVAgLsjXk_feJnPIcW_zPzPZaNaXG7Ocgeh0L4V-ZJX9cmIPefp7xDKbfSweU7IjTsdiOBsYgFZsqCg_obVGKRm3L24GZqltdmbpYZba9Q5Ta9elz0_-o9tjeFl5zluB7ycAa5HHiNkUH3Gsf4oZ_WzCFF_z_weHzI7G</recordid><startdate>20190601</startdate><enddate>20190601</enddate><creator>Zarka, M.</creator><creator>Hay, E.</creator><creator>Ostertag, A.</creator><creator>Marty, C.</creator><creator>Chappard, C.</creator><creator>Oudet, F.</creator><creator>Engelke, K.</creator><creator>Laredo, J.D.</creator><creator>Cohen-Solal, M.</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>1XC</scope><scope>VOOES</scope><orcidid>https://orcid.org/0000-0003-3179-4432</orcidid><orcidid>https://orcid.org/0000-0001-9875-4123</orcidid></search><sort><creationdate>20190601</creationdate><title>Microcracks in subchondral bone plate is linked to less cartilage damage</title><author>Zarka, M. ; Hay, E. ; Ostertag, A. ; Marty, C. ; Chappard, C. ; Oudet, F. ; Engelke, K. ; Laredo, J.D. ; Cohen-Solal, M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c434t-2ad729006ad65e3ba8b32e1861fb2de524f65d43b7654078acedb62652b1d9703</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Bone</topic><topic>Life Sciences</topic><topic>Mechanical loading</topic><topic>Microcracks</topic><topic>Osteoarthritis</topic><topic>Osteocytes</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zarka, M.</creatorcontrib><creatorcontrib>Hay, E.</creatorcontrib><creatorcontrib>Ostertag, A.</creatorcontrib><creatorcontrib>Marty, C.</creatorcontrib><creatorcontrib>Chappard, C.</creatorcontrib><creatorcontrib>Oudet, F.</creatorcontrib><creatorcontrib>Engelke, K.</creatorcontrib><creatorcontrib>Laredo, J.D.</creatorcontrib><creatorcontrib>Cohen-Solal, M.</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><collection>Hyper Article en Ligne (HAL) (Open Access)</collection><jtitle>Bone (New York, N.Y.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zarka, M.</au><au>Hay, E.</au><au>Ostertag, A.</au><au>Marty, C.</au><au>Chappard, C.</au><au>Oudet, F.</au><au>Engelke, K.</au><au>Laredo, J.D.</au><au>Cohen-Solal, M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Microcracks in subchondral bone plate is linked to less cartilage damage</atitle><jtitle>Bone (New York, N.Y.)</jtitle><addtitle>Bone</addtitle><date>2019-06-01</date><risdate>2019</risdate><volume>123</volume><spage>1</spage><epage>7</epage><pages>1-7</pages><issn>8756-3282</issn><eissn>1873-2763</eissn><eissn>8756-3282</eissn><notes>ObjectType-Article-1</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-2</notes><notes>content type line 23</notes><abstract>Osteoarthritis (OA) is a disease of the whole joint characterized by cartilage loss and subchondral bone remodeling. The role of microcracks in cartilage integrity and subchondral bone homeostasis is not fully understood. The main goal of this work was to evaluate microcrack density in both calcified cartilage and subchondral bone plate in relation to cartilage damage in humans and to better define the association of microcracks and osteocyte density in subchondral bone.
We investigated 18 bone cores from cadaveric human knees that were stained with En-Bloc Basic Fuchsin. We quantified microcrack density, osteocyte density, cartilage surfaces and cartilage damage. The presence of microcracks was confirmed for each bone core by scanning electron microscopy. Finally, trabecular subchondral bone parameters were measured by micro-CT.
Microcracks were detected in both calcified cartilage and subchondral bone plate. The density of microcracks in both calcified cartilage (CC) and subchondral bone plate (SBP) was negatively correlated with cartilage damage (r = −0.45, p < 0.05). The presence of microcracks in SBP was associated with a lower histological OA score. Osteocytes formed a dendrite network that abruptly stopped at the border of calcified cartilage. Osteocyte density in subchondral bone plate was increased in the presence of microcracks in calcified cartilage.
Subchondral bone plate microcracks might be required for maintaining cartilage homeostasis. Microcracks in calcified cartilage may trigger osteocyte density in subchondral bone plate with subsequent regulation of subchondral bone remodeling to prevent cartilage damage.
•Subchondral bone contains a high density of osteocytes, the dendrites of which are bordering the calcified cartilage•Microcracks are negatively correlated with cartilage damage, suggesting that they might be required for cartilage homeostasis•Microcracks in the calcified cartilage are associated with increased osteocyte density in the subchondral bone•Microcracks in the calcified cartilage might regulate subchondral bone remodeling</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>30862540</pmid><doi>10.1016/j.bone.2019.03.011</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0003-3179-4432</orcidid><orcidid>https://orcid.org/0000-0001-9875-4123</orcidid><oa>free_for_read</oa></addata></record> |
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| source | Elsevier |
| subjects | Bone Life Sciences Mechanical loading Microcracks Osteoarthritis Osteocytes |
| title | Microcracks in subchondral bone plate is linked to less cartilage damage |
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