Microcracks in subchondral bone plate is linked to less cartilage damage

Osteoarthritis (OA) is a disease of the whole joint characterized by cartilage loss and subchondral bone remodeling. The role of microcracks in cartilage integrity and subchondral bone homeostasis is not fully understood. The main goal of this work was to evaluate microcrack density in both calcifie...

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Bibliographic Details
Published in:Bone (New York, N.Y.) N.Y.), 2019-06, Vol.123, p.1-7
Main Authors: Zarka, M., Hay, E., Ostertag, A., Marty, C., Chappard, C., Oudet, F., Engelke, K., Laredo, J.D., Cohen-Solal, M.
Format: Article
Language:English
Subjects:
Bone
Life Sciences
Mechanical loading
Microcracks
Osteoarthritis
Osteocytes
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Summary:Osteoarthritis (OA) is a disease of the whole joint characterized by cartilage loss and subchondral bone remodeling. The role of microcracks in cartilage integrity and subchondral bone homeostasis is not fully understood. The main goal of this work was to evaluate microcrack density in both calcified cartilage and subchondral bone plate in relation to cartilage damage in humans and to better define the association of microcracks and osteocyte density in subchondral bone. We investigated 18 bone cores from cadaveric human knees that were stained with En-Bloc Basic Fuchsin. We quantified microcrack density, osteocyte density, cartilage surfaces and cartilage damage. The presence of microcracks was confirmed for each bone core by scanning electron microscopy. Finally, trabecular subchondral bone parameters were measured by micro-CT. Microcracks were detected in both calcified cartilage and subchondral bone plate. The density of microcracks in both calcified cartilage (CC) and subchondral bone plate (SBP) was negatively correlated with cartilage damage (r = −0.45, p 
ISSN:8756-3282
1873-2763
8756-3282
DOI:10.1016/j.bone.2019.03.011