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Prediction of Ventricular Mechanics After Pulmonary Valve Replacement in Tetralogy of Fallot by Biomechanical Modeling: A Step Towards Precision Healthcare
Clinical indicators of heart function are often limited in their ability to accurately evaluate the current mechanical state of the myocardium. Biomechanical modeling has been shown to be a promising tool in addition to clinical indicators. By providing a patient-specific measure of myocardial activ...
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Published in: | Annals of biomedical engineering 2021-12, Vol.49 (12), p.3339-3348 |
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Main Authors: | , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | Clinical indicators of heart function are often limited in their ability to accurately evaluate the current mechanical state of the myocardium. Biomechanical modeling has been shown to be a promising tool in addition to clinical indicators. By providing a patient-specific measure of myocardial active stress (contractility), biomechanical modeling can enhance the precision of the description of patient’s pathophysiology at any given point in time. In this work we aim to explore the ability of biomechanical modeling to predict the response of ventricular mechanics to the progressively decreasing afterload in repaired tetralogy of Fallot (rTOF) patients undergoing pulmonary valve replacement (PVR) for significant residual right ventricular outflow tract obstruction (RVOTO). We used 19 patient-specific models of patients with rTOF prior to pulmonary valve replacement (PVR), denoted as PSM
pre
, and patient-specific models of the same patients created post-PVR (PSM
post
)—both created in our previous published work. Using the PSM
pre
and assuming cessation of the pulmonary regurgitation and a progressive decrease of RVOT resistance, we built relationships between the contractility and RVOT resistance post-PVR. The predictive value of such
in silico
obtained relationships were tested against the PSM
post
, i.e. the models created from the actual post-PVR datasets. Our results show a linear 1-dimensional relationship between the
in silico
predicted contractility post-PVR and the RVOT resistance. The predicted contractility was close to the contractility in the PSM
post
model with a mean (± SD) difference of 6.5 (± 3.0)%. The relationships between the contractility predicted by
in silico
PVR vs. RVOT resistance have a potential to inform clinicians about hypothetical mechanical response of the ventricle based on the degree of pre-operative RVOTO. |
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ISSN: | 0090-6964 1573-9686 |
DOI: | 10.1007/s10439-021-02895-9 |