Moderate Differences in Plasma Leptin in Mares Have no Effect on Either the Amino Acid or the Fatty Acid Composition of the Uterine Fluid

•Differences in circulating leptin levels within a physiological range did not affect the amino acid and fatty acid composition of the uterine fluid in the mare.•Relative abundancies of amino acids and fatty acids differed between blood plasma and the uterine fluid in the mare.•Mechanisms of a possi...

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Published in:Journal of equine veterinary science 2022-02, Vol.109, p.103827-103827, Article 103827
Main Authors: Drews, Barbara, Milojevic, Vladimir, Robles, Morgane, Wimel, Laurence, Dubois, Cédric, Rudolf Vegas, Alba, Giller, Katrin, Chavatte-Palmer, Pascale, Daniel, Hannelore, Giesbertz, Pieter, Bruckmaier, Rupert M., Ulbrich, Susanne E.
Format: Article
Language:English
Subjects:
Amino Acids
Animal biology
Animals
Body condition, Reproduction
Fatty Acids
Female
Horse
Horses
Hypothalamo-Hypophyseal System - metabolism
Leptin
Life Sciences
Metabolic hormones
Pituitary-Adrenal System - metabolism
Plasma - metabolism
Retrospective Studies
Uterine fluid
Veterinary medicine and animal Health
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Summary:•Differences in circulating leptin levels within a physiological range did not affect the amino acid and fatty acid composition of the uterine fluid in the mare.•Relative abundancies of amino acids and fatty acids differed between blood plasma and the uterine fluid in the mare.•Mechanisms of a possible local effect of leptin on the amino acid and fatty acid composition of the equine uterine fluid are discussed. Female mammalian reproductive functions are closely linked to body condition and metabolic status. Energy homeostasis is regulated by endocrine hormones such as insulin, IGF-I, leptin, and adiponectin via the hypothalamic-pituitary-adrenal axis. These metabolic hormones and their receptors are also expressed in reproductive tissues and the embryo. We investigated the relationship between circulating leptin and the fatty acid (FA) and amino acid (AA) composition of the equine uterine fluid (UF) and peripheral blood plasma (BP) by using a mass spectrometry-based approach. UF and BP were collected from ten broodmares on days 6 and 7 post ovulation, respectively. The mares were retrospectively assigned to two groups according to their BP leptin concentrations (high leptin [> 1.6 ng/mL] versus low leptin [
ISSN:0737-0806
1542-7412
DOI:10.1016/j.jevs.2021.103827