Physical performance level in sarcomeric mitochondria creatine kinase knockout mouse model throughout ageing

The objective of the present study was to establish the role of sarcomeric mitochondrial creatine kinase (Mt-CK) in muscle energy output during exercise in a murine model of ageing (the Mt-CK knock-out mouse, Mt-CK−/−). Three age groups of Mt-CK−/− mice and control male mice (6, 9, and 18 months of...

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Bibliographic Details
Published in:Experimental gerontology 2021-04, Vol.146, p.111246-111246, Article 111246
Main Authors: Niel, R., Le Moyec, L., Launay, T., Mille-Hamard, L., Triba, M.N., Maciejak, O., Billat, V.L., Momken, I.
Format: Article
Language:English
Subjects:
Ageing
Efficiency
Exercise performance
Life Sciences
Mitochondrial creatine kinase
Skeletal muscle
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Summary:The objective of the present study was to establish the role of sarcomeric mitochondrial creatine kinase (Mt-CK) in muscle energy output during exercise in a murine model of ageing (the Mt-CK knock-out mouse, Mt-CK−/−). Three age groups of Mt-CK−/− mice and control male mice (6, 9, and 18 months of age) underwent incremental treadmill running tests. The maximum speed (Vpeak) and maximal oxygen consumption (VO2peak) values were recorded. Urine samples were analyzed using metabolomic techniques. The skeletal muscle (quadriceps) expression of proteins involved in mitochondria biogenesis, peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α) and dynamin-related GTPase mitofusin 2 (Mnf2) were quantified. The VO2 peak (normalized to heart weight: HW) of 18-month-old (mo) Mt-CK−/− mice was 27% (p 
ISSN:0531-5565
1873-6815
DOI:10.1016/j.exger.2021.111246