Systematic review and meta‐analysis: the incidence and prevalence of paediatric coeliac disease across Europe

Summary Background Coeliac disease is one of the most prevalent immune‐mediated gastrointestinal disorders in children. Aim To review the incidence and prevalence of paediatric coeliac disease, and their trends, regionally across Europe, overall and according to age at diagnosis. Methods Systematic...

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Published in:Alimentary pharmacology & therapeutics 2021-07, Vol.54 (2), p.109-128
Main Authors: Roberts, Stephen E., Morrison‐Rees, Sian, Thapar, Nikhil, Benninga, Marc A., Borrelli, Osvaldo, Broekaert, Ilse, Dolinsek, Jernej, Martin‐de‐Carpi, Javier, Mas, Emmanuel, Miele, Erasmo, Pienar, Corina, Ribes‐Koninckx, Carmen, Thomassen, Rut A., Thomson, Mike, Tzivinikos, Christos, Thorne, Kymberley, John, Ann, Williams, John G.
Format: Article
Language:English
Subjects:
Antibodies
Celiac disease
Diagnosis
Gastrointestinal diseases
Human health and pathology
Life Sciences
Meta-analysis
Pediatrics
Serology
Systematic review
Transglutaminase 2
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Summary:Summary Background Coeliac disease is one of the most prevalent immune‐mediated gastrointestinal disorders in children. Aim To review the incidence and prevalence of paediatric coeliac disease, and their trends, regionally across Europe, overall and according to age at diagnosis. Methods Systematic review and meta‐analysis from January 1, 1950 to December 31, 2019, based on PubMed, CINAHL and the Cochrane Library, searches of grey literature and websites and hand searching of reference lists. A total of 127 eligible studies were included. Results The prevalence of previously undiagnosed coeliac disease from screening surveys (histology based) ranged from 0.10% to 3.03% (median = 0.70%), with a significantly increasing annual trend (P = 0.029). Prevalence since 2000 was significantly higher in northern Europe (1.60%) than in eastern (0.98%), southern (0.69%) and western (0.60%) Europe. Large increases in the incidence of diagnosed coeliac disease across Europe have reached 50 per 100 000 person‐years in Scandinavia, Finland and Spain. The median age at diagnosis increased from 1.9 years before 1990 to 7.6 since 2000. Larger increases in incidence were found in older age groups than in infants and ages
ISSN:0269-2813
1365-2036
0269-2813
DOI:10.1111/apt.16337