Long-term toxicological effects of persistent luminescence nanoparticles after intravenous injection in mice

[Display omitted] The ZnGa1.995Cr0.005O4 persistent luminescence nanoparticles offer the promise of revolutionary tools for biological imaging with applications such as cell tracking or tumor detection. They can be re-excited through living tissues by visible photons, allowing observations without a...

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Bibliographic Details
Published in:International journal of pharmaceutics 2017-11, Vol.532 (2), p.686-695
Main Authors: Ramírez-García, Gonzalo, Gutiérrez-Granados, Silvia, Gallegos-Corona, Marco A., Palma-Tirado, Lourdes, d’Orlyé, Fanny, Varenne, Anne, Mignet, Nathalie, Richard, Cyrille, Martínez-Alfaro, Minerva
Format: Article
Language:English
Subjects:
Animals
Bioengineering
Blood Cell Count
Chemical Sciences
Chromium - toxicity
chronic toxicology
Comet Assay
Engineering Sciences
Gallium - toxicity
Hydroxylation
Imaging
Injections, Intravenous
Kidney - drug effects
Life Sciences
Liver - drug effects
Liver - pathology
Liver - ultrastructure
Luminescence
Lung - drug effects
Male
Materials
Mice, Inbred BALB C
Nanoparticles - toxicity
nanoprobes
Nitric Oxide - metabolism
optical imaging
Optics
Organic chemistry
Oxides - toxicity
PEG functionalization
Persistent luminescence nanoparticles
Physics
Polyethylene Glycols - chemistry
Spleen - drug effects
Spleen - ultrastructure
Zinc - toxicity
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Summary:[Display omitted] The ZnGa1.995Cr0.005O4 persistent luminescence nanoparticles offer the promise of revolutionary tools for biological imaging with applications such as cell tracking or tumor detection. They can be re-excited through living tissues by visible photons, allowing observations without any time constraints and avoiding the undesirable auto-fluorescence signals observed when fluorescent probes are used. Despite all these advantages, their uses demand extensive toxicological evaluation and control. With this purpose, mice were injected with a single intravenous administration of hydroxylated or PEGylated persistent luminescence nanoparticles at different concentrations and then a set of standard tests were carried out 1day, 1 month and 6 months after the administration. High concentrations of hydroxylated nanoparticles generate structural alterations at histology level, endoplasmic reticulum damage and oxidative stress in liver, as well as rising in white blood cells counts. A mechanism involving the endoplasmic reticulum damage could be the responsible of the observed injuries in case of ZGO-OH. On the contrary, no toxicological effects related to PEGylated nanoprobes treatment were noted during our in vivo experiments, denoting the protective effect of PEG-functionalization and thereby, their potential as biocompatible in vivo diagnostic probes.
ISSN:0378-5173
1873-3476
DOI:10.1016/j.ijpharm.2017.07.015