Synthetic cannabinoids in e-liquids: A proton and fluorine NMR analysis from a conventional spectrometer to a compact one

•NMR was applied to the analysis of e-liquids containing synthetic cannabinoids.•The 1H NMR profiles of 13 samples of e-liquids were obtained with HF and LF NMR.•Fluorinated synthetic cannabinoids were quantified using HF and LF 19F NMR.•Quantitative results were obtained for the five synthetic cann...

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Bibliographic Details
Published in:Forensic science international 2021-07, Vol.324, p.110813-110813, Article 110813
Main Authors: Wu, Nao, Danoun, Saïda, Balayssac, Stéphane, Malet-Martino, Myriam, Lamoureux, Catherine, Gilard, Véronique
Format: Article
Language:English
Subjects:
19F NMR
Cannabinoid
Cannabinoids
Chemical Sciences
Chromatography
Compact NMR
Customs
Data processing
E-cigarette
E-liquid
Electronic cigarettes
Experiments
Feeding behavior
Fluorine
Forensic sciences
Laboratories
Liquids
Mass spectrometry
NMR
Nuclear magnetic resonance
QNMR
Quantitative analysis
Scientific imaging
Software
Spectrometers
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Summary:•NMR was applied to the analysis of e-liquids containing synthetic cannabinoids.•The 1H NMR profiles of 13 samples of e-liquids were obtained with HF and LF NMR.•Fluorinated synthetic cannabinoids were quantified using HF and LF 19F NMR.•Quantitative results were obtained for the five synthetic cannabinoids detected. [Display omitted] The 1H NMR profiles of 13 samples of e-liquids supplied by French customs were obtained with high-field and low-field NMR. The high-field 1H NMR spectra allowed the detection of matrix signals, synthetic cannabinoids, and flavouring compounds. Quantitative results were obtained for the five synthetic cannabinoids detected: JWH-210, 5F-MDMB-PICA, 5F-ADB, 5F-AKB48, and ADB-FUBINACA. Conventional GC-MS analysis was used to confirm compound identification. Fluorine-19 NMR was proposed for the quantification of fluorinated synthetic cannabinoids and was successfully implemented on both 400 MHz and 60 MHz NMR spectrometers. This study based on few examples explored the potentiality of low-field NMR for quantitative and quantitative analysis of synthetic cannabinoids in e-liquids.
ISSN:0379-0738
1872-6283
DOI:10.1016/j.forsciint.2021.110813