Correlation between tumor growth and hormonal therapy with MR signal characteristics of desmoid-type fibromatosis: A preliminary study

To evaluate the impact of hormonal therapy on MRI characteristics of desmoid-type fibromatosis on T1-weighted, T2-weighted fat-saturated and post-contrast sequences. Nineteen patients with histologically-proven desmoid-type fibromatosis were prospectively followed up on MR imaging. Eight patients un...

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Bibliographic Details
Published in:Diagnostic and interventional imaging 2019-01, Vol.100 (1), p.47-55
Main Authors: Gondim Teixeira, P.A., Chanson, A., Verhaeghe, J.-L., Lecocq, S., Louis, M., Hossu, G., Blum, A.
Format: Article
Language:English
Subjects:
Aggressive fibromatosis
Bioengineering
Computer Science
Desmoid type fibromatosis
Follow-up
Human health and pathology
Life Sciences
Medical Imaging
MR imaging
Nuclear medicine
Tamoxifen
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Summary:To evaluate the impact of hormonal therapy on MRI characteristics of desmoid-type fibromatosis on T1-weighted, T2-weighted fat-saturated and post-contrast sequences. Nineteen patients with histologically-proven desmoid-type fibromatosis were prospectively followed up on MR imaging. Eight patients underwent hormonal therapy and 11 were only surveyed. Change in tumor size during follow-up was analyzed according to RECIST. Signal intensity on T1-weighted, T2-weighted fat-saturated and T1-weighted fat-saturated post-contrast images was graded from 0 to 5 using adjacent normal muscle as reference. Findings were compared with tumor growth and treatment option. There were seven men and 12 women with a mean age of 42.2±16.4 (SD) years (range: 18 - 64 years) yielding twenty-six follow-up periods: eight of tumor progression and 18 of tumor stability/regression (some tumors exhibited more than one behavior type). Hormonal therapy was associated with tumor stability or regression (P=0.0207). There was a significant reduction in enhancement among treated patients with stable/regressing disease (P=0.049). The mean variation in enhancement grade was −1.3±1.2 in these patients. All successfully treated patients presented a reduction in enhancement. Lesions with marked low enhancement or very low signal on T2-weighted images were rare in progressing lesions (0% and 13%). Hormonal therapy has an impact on desmoid-type fibromatosis signal characteristics reducing lesion enhancement.
ISSN:2211-5684
2211-5684
DOI:10.1016/j.diii.2018.06.007