Death sentence: The tale of a fallen endoplasmic reticulum

Endoplasmic Reticulum (ER) stress signaling is an adaptive mechanism triggered when protein folding demand overcomes the folding capacity of this compartment, thereby leading to the accumulation of improperly folded proteins. This stress signaling pathway is named the Unfolded Protein Response (UPR)...

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Bibliographic Details
Published in:Biochimica et biophysica acta. Molecular cell research 2021-05, Vol.1868 (6), p.119001-119001, Article 119001
Main Authors: McGrath, Eoghan P., Centonze, Federica G., Chevet, Eric, Avril, Tony, Lafont, Elodie
Format: Article
Language:English
Subjects:
Apoptosis
Autophagy
Cancer
Cell death
Endoplasmic reticulum
Ferroptosis
Life Sciences
Pyroptosis
Unfolded protein response
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Summary:Endoplasmic Reticulum (ER) stress signaling is an adaptive mechanism triggered when protein folding demand overcomes the folding capacity of this compartment, thereby leading to the accumulation of improperly folded proteins. This stress signaling pathway is named the Unfolded Protein Response (UPR) and aims at restoring ER homeostasis. However, if this fails, mechanisms orienting cells towards death processes are initiated. Herein, we summarize the most recent findings connecting ER stress and the UPR with identified death mechanisms including apoptosis, necrosis, pyroptosis, ferroptosis, and autophagy. We highlight new avenues that could be investigated and controlled through actionable mechanisms in physiology and pathology. •Endoplasmic Stress signaling is functionally linked to multiple Regulated Cell Death (RCD) pathways.•RCD modes include pyroptosis, apoptosis, necroptosis and autophagy-associated cell death.•ER-stress-induced RCD pathways are functionally intertwined.•Targeting RCD will likely be useful in controlling ER stress-associated diseases.
ISSN:0167-4889
1879-2596
DOI:10.1016/j.bbamcr.2021.119001