IKZF1 alterations predict poor prognosis in adult and pediatric T-ALL

Patient outcomes in T-cell acute lymphoblastic leukemia and lymphoblastic lymphoma (T-ALL/LBL) can be difficult to predict. Simonin et al report deletions and mutations in the gene encoding the transcription factor IKAROS among 1260 children and adults with immature T-ALL/LBL, defining its frequency...

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Bibliographic Details
Published in:Blood 2021-03, Vol.137 (12), p.1690-1694
Main Authors: Simonin, Mathieu, Lhermitte, Ludovic, Dourthe, Marie-Emilie, Lengliné, Etienne, Graux, Carlos, Grardel, Nathalie, Cayuela, Jean-Michel, Arnoux, Isabelle, Gandemer, Virginie, Ifrah, Norbert, Dombret, Hervé, Baruchel, André, Macintyre, Elizabeth, Petit, Arnaud, Boissel, Nicolas, Asnafi, Vahid
Format: Article
Language:English
Subjects:
Hematology
Human health and pathology
Life Sciences
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Summary:Patient outcomes in T-cell acute lymphoblastic leukemia and lymphoblastic lymphoma (T-ALL/LBL) can be difficult to predict. Simonin et al report deletions and mutations in the gene encoding the transcription factor IKAROS among 1260 children and adults with immature T-ALL/LBL, defining its frequency and, importantly, its association with poor outcome in multivariate models. Pathogenic alterations in IKZF1 now can be added to minimal residual disease detection and the established 4-gene oncogenetic classifier to better predict poor outcomes of T-ALL/LBL.
ISSN:0006-4971
1528-0020
DOI:10.1182/blood.2020007959