Topological Requirements for CI-M6PR-Mediated Cell Uptake

The 300 kDa cation-independent M6P receptor (CI-MPR) mediates ligand internalization and trafficking to the endolysosomal compartments. Because of its endocytotic nature, it has been recognized as a promising class of receptors for target component delivery. Its cellular uptake involves the simultan...

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Bibliographic Details
Published in:Bioconjugate chemistry 2019-10, Vol.30 (10), p.2533-2538
Main Authors: Ali, Lamiaa M. A, Simon, Matthieu, El Cheikh, Khaled, Aguesseau-Kondrotas, Julie, Godefroy, Anastasia, Nguyen, Christophe, Garcia, Marcel, Morère, Alain, Gary-Bobo, Magali, Maillard, Ludovic
Format: Article
Language:English
Subjects:
Carbohydrates
Chemical Sciences
Dimers
Glycoconjugates
Internalization
Life Sciences
Ligands
Receptors
Topology
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Summary:The 300 kDa cation-independent M6P receptor (CI-MPR) mediates ligand internalization and trafficking to the endolysosomal compartments. Because of its endocytotic nature, it has been recognized as a promising class of receptors for target component delivery. Its cellular uptake involves the simultaneous binding of two protein units resulting in the formation of receptor dimers. While many multivalent glycoconjugates have been reported to date, little is known about the topological requests to induce an effective recruitment of CI-MPRs. We herein describe the synthesis and cell uptake ability of a set of highly organized glycoclusters bearing one to three saccharide units. The spatial arrangement of carbohydrate ligands is ensured by a heterocyclic γ-peptide central core.
ISSN:1043-1802
1520-4812
DOI:10.1021/acs.bioconjchem.9b00590