Spontaneous membrane-less multi-compartmentalization via aqueous two-phase separation in complex coacervate micro-droplets

Polyelectrolyte/nucleotide multiphase complex coacervate droplets are produced by internalized aqueous two-phase separation and used for the spatially dependent chemical transfer of sugar molecules, providing a step towards the development of membrane-free "organelles" within coacervate-ba...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2020-10, Vol.56 (84), p.12717-12720
Main Authors: Moreau, Nicolette G, Martin, Nicolas, Gobbo, Pierangelo, Tang, T-Y Dora, Mann, Stephen
Format: Article
Language:English
Subjects:
Biotechnology
Chemical Sciences
Condensed Matter
Droplets
Fluorescence
Life Sciences
Membranes
Nucleotides
Organelles
Phase diagrams
Phase separation
Physics
Polyelectrolytes
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Summary:Polyelectrolyte/nucleotide multiphase complex coacervate droplets are produced by internalized aqueous two-phase separation and used for the spatially dependent chemical transfer of sugar molecules, providing a step towards the development of membrane-free "organelles" within coacervate-based protocells.
ISSN:1359-7345
1364-548X
DOI:10.1039/d0cc05399f