Recent Advances on Catalytic Osmium‐Free Olefin syn‐Dihydroxylation

The syn‐dihydroxylation of olefinic group is one of the most important synthetic transformations which leads to the controlled formation of syn‐diol. Such 1,2‐diol structure is integrated into more complex architectures and substantially participates in the development of biologically active molecul...

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Bibliographic Details
Published in:European journal of organic chemistry 2021-02, Vol.2021 (6), p.877-896
Main Authors: Achard, Thierry, Bellemin‐Laponnaz, Stéphane
Format: Article
Language:English
Subjects:
1, 2‐Diols
Alkenes
Asymmetric catalysis
Chemical Sciences
Coordination compounds
Fine chemicals
Metal‐catalysis
Osmium
Oxidation
syn‐Dihydroxylation
syn‐Oxidation
Transition metal compounds
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Summary:The syn‐dihydroxylation of olefinic group is one of the most important synthetic transformations which leads to the controlled formation of syn‐diol. Such 1,2‐diol structure is integrated into more complex architectures and substantially participates in the development of biologically active molecules and other fine chemicals. This minireview describes recent evolution of this research field in the past decade, surveying osmium‐free and more eco‐compatible system and in particular the direct oxidation of olefins catalyzed by transition metal complexes. syn‐1,2‐Diols are valuable scaffolds for building a vast number of biologically active compounds and are also important synthetic intermediates in organic synthesis. This review focuses on a concise summary of the main metal‐catalyzed methods of olefin syn‐dihydroxylation developed over the past ten years to circumvent the use of osmium.
ISSN:1434-193X
1099-0690
DOI:10.1002/ejoc.202001209