Angiographic predictors of outcome in myocardial infarction patients presenting with cardiogenic shock: A CULPRIT-SHOCK angiographic substudy

Aims: To determine the prognostic impact of pre and post-PCI TIMI Flow Grade (TIMI) and TIMI Myocardial Perfusion (TMPG) in a well-defined group of patients with cardiogenic shock due to acute myocardial infarction.Methods and results: Patients with infarct-related cardiogenic shock randomized into...

Full description

Saved in:
Bibliographic Details
Published in:EuroIntervention 2021-02
Main Authors: Overtchouk, Pavel, Barthelemy, Olvier, Hauguel-Moreau, Marie, Guedeney, Paul, Rouanet, Stéphanie, Zeitouni, Michel, Silvain, Johanne, Collet, Jean-Philippe, Vicaut, Eric, Zeymer, Uwe, Desch, Steffen, Thiele, Holger, Montalescot, Gilles
Format: Article
Language:English
Subjects:
Life Sciences
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Aims: To determine the prognostic impact of pre and post-PCI TIMI Flow Grade (TIMI) and TIMI Myocardial Perfusion (TMPG) in a well-defined group of patients with cardiogenic shock due to acute myocardial infarction.Methods and results: Patients with infarct-related cardiogenic shock randomized into the CULPRIT-SHOCK trial were included in the angiographic predictor analysis whenever their TIMI or TMPG was available in the Corelab database (96.9% of cases). A multivariable logistic regression analysis, adjusted on non-angiographic covariates, was performed to investigate if TIMI or TMPG, were independently associated with all-cause mortality or renal replacement therapy up to 1 year. Pre-PCI TIMI and TMPG did not impact mortality. When analyzed in separate multivariable models, post-PCI TIMI 3 and TMPG grade 3 were both significantly associated with reduced risk of 30-day mortality: aOR 0.61 (95%CI: 0.38-0.97, p=0.037) and 0.46 (95%CI: 0.29-0.72, p
ISSN:1774-024X
DOI:10.4244/EIJ-D-20-00139