Clinical evaluation of the Uphold LITE mesh for the surgical treatment of anterior and apical prolapse: A prospective, multicentre trial

Aims To evaluate the safety and efficacy of the Uphold LITE mesh in the treatment of pelvic organ prolapse at 12‐month follow‐up. Methods Women undergoing a mesh surgery due to an anterior prolapse plus a symptomatic anterior prolapse (classed as pelvic organ prolapse quantification stage ≥2) were i...

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Published in:Neurourology and urodynamics 2019-11, Vol.38 (8), p.2242-2249
Main Authors: Allegre, Lucie, Debodinance, Philippe, Demattei, Christophe, Fabbro Peray, Pascale, Cayrac, Mélanie, Fritel, Xavier, Courtieu, Christophe, Fatton, Brigitte, Tayrac, Renaud
Format: Article
Language:English
Subjects:
Aged
complications
composite outcome
Female
Follow-Up Studies
Human health and pathology
Humans
Life Sciences
Middle Aged
Patient Safety
Patients
Pelvic organ prolapse
Pelvic Organ Prolapse - psychology
Pelvic Organ Prolapse - surgery
Prospective Studies
Quality of Life
Recurrence
Reoperation
Risk Factors
Surgery
Surgical Mesh
transvaginal mesh
Treatment Outcome
Uphold LITE
Urologic Surgical Procedures - methods
Urology and Nephrology
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Summary:Aims To evaluate the safety and efficacy of the Uphold LITE mesh in the treatment of pelvic organ prolapse at 12‐month follow‐up. Methods Women undergoing a mesh surgery due to an anterior prolapse plus a symptomatic anterior prolapse (classed as pelvic organ prolapse quantification stage ≥2) were included in this prospective, multicentre, observational study. The primary endpoint was a composite outcome including a good anatomical correction, no prolapse symptoms, and no reintervention for an anterior or apical recurrent prolapse within 12 months of surgery. Secondary outcomes included safety, improvements in quality of life (QoL), and risk factor for recurrence. This study was registered with ClinicalTrials.gov, number NCT01559168. Results A total of 121 patients were included. Symptomatic and anatomic cure rates were 94% (95 of 101) and 76.8% (76 of 99), respectively. The composite success rate was 72.4% (71 of 98). The rate of reoperation for apical or anterior recurrent prolapse was 3.9% (4 of 103). Anatomical anterior or apical recurrence occurred in 18.2% (18 of 97) and 7.2% (7 of 97) of patients, respectively. The composite success rate was significantly higher in centres where more than 30 patients had been treated (80% vs 50%; P = .045). The rate of serious complication was 5.4% (6 of 111). Improvements were recorded in QoL including sexual function. Conclusions The Uphold LITE mesh procedure provides satisfactory outcomes in the treatment of anterior and apical prolapse, particularly in high‐volume centres. The rates of adverse effects and reintervention for recurrent prolapse were acceptable.
ISSN:0733-2467
1520-6777
DOI:10.1002/nau.24125