In vivo confocal imaging of the retina in animal models using scanning laser ophthalmoscopy

Scanning-laser ophthalmoscopy is a technique for confocal imaging of the eye in vivo. The use of lasers of different wavelengths allows to obtain information about specific tissues and layers due to their reflection and transmission characteristics. In addition, fluorescent dyes excitable in the blu...

Full description

Saved in:
Bibliographic Details
Published in:Vision research (Oxford) 2005-12, Vol.45 (28), p.3512-3519
Main Authors: Seeliger, Mathias W., Beck, Susanne C., Pereyra-Muñoz, Naira, Dangel, Susann, Tsai, Jen-Yue, Luhmann, Ulrich F.O., van de Pavert, Serge A., Wijnholds, Jan, Samardzija, Marijana, Wenzel, Andreas, Zrenner, Eberhart, Narfström, Kristina, Fahl, Edda, Tanimoto, Naoyuki, Acar, Niyazi, Tonagel, Felix
Format: Article
Language:English
Subjects:
Angiography
Animal models
Animals
Fluorescein Angiography
Indocyanine Green
Lasers
Life Sciences
Mice
Microscopy, Confocal - instrumentation
Microscopy, Confocal - methods
Microscopy, Fluorescence - instrumentation
Microscopy, Fluorescence - methods
Models, Animal
Ophthalmoscopy - methods
Retina - pathology
Retinal degenerations
Retinal Diseases - pathology
Scanning-laser ophthalmoscopy
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Scanning-laser ophthalmoscopy is a technique for confocal imaging of the eye in vivo. The use of lasers of different wavelengths allows to obtain information about specific tissues and layers due to their reflection and transmission characteristics. In addition, fluorescent dyes excitable in the blue and infrared range offer a unique access to the vascular structures associated with each layer. In animal models, a further enhancement in specificity can be obtained by GFP expression under control of tissue-specific promotors. Important fields of application are studies in retinal degenerations and the follow-up of therapeutic intervention.
ISSN:0042-6989
1878-5646
0042-6989
DOI:10.1016/j.visres.2005.08.014