Bone Morphogenetic Protein 5 Expression in the Rat Ovary: Biological Effects on Granulosa Cell Proliferation and Steroidogenesis

Recently, the role of several elements of the bone morphogenetic protein (BMP) family has been studied in the ovary, some of them being crucial for ovarian function. In the present work, we have studied bone morphogenetic protein 5 (BMP5) expression and its biological role in the rat ovary. BMP5 is...

Full description

Saved in:
Bibliographic Details
Published in:Biology of reproduction 2005-12, Vol.73 (6), p.1102-1108
Main Authors: PIERRE, Alice, PISSELET, Claudine, DUPONT, Joelle, BONTOUX, Martine, MONGET, Philippe
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Bone Morphogenetic Protein 5
Bone Morphogenetic Proteins - genetics
Bone Morphogenetic Proteins - metabolism
Bone Morphogenetic Proteins - pharmacology
Cell Proliferation - drug effects
Cholesterol Side-Chain Cleavage Enzyme - drug effects
Cholesterol Side-Chain Cleavage Enzyme - metabolism
Cyclin D2
Cyclins - drug effects
Cyclins - metabolism
Estradiol - metabolism
Female
Follicle Stimulating Hormone - pharmacology
Follistatin - pharmacology
Fundamental and applied biological sciences. Psychology
Gene Expression Regulation
Granulosa Cells - cytology
Granulosa Cells - drug effects
Granulosa Cells - metabolism
Life Sciences
Mammalian female genital system
Morphology. Physiology
Ovary
Phosphoproteins - drug effects
Phosphoproteins - metabolism
Progesterone - metabolism
Rats
Rats, Wistar
Reproductive Biology
RNA, Messenger - metabolism
Steroids - metabolism
Vertebrates: reproduction
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Recently, the role of several elements of the bone morphogenetic protein (BMP) family has been studied in the ovary, some of them being crucial for ovarian function. In the present work, we have studied bone morphogenetic protein 5 (BMP5) expression and its biological role in the rat ovary. BMP5 is expressed by rat granulosa cells (GCs) and exerts specific biological effects on proliferation and steroidogenesis of these cells in an autocrine manner. These effects were shown to be associated with an increase in cyclin D2 protein level and a decrease in steroidogenic acute regulatory (StAR) protein expression in GCs in vitro. Ultimately, BMP5 actions were inhibited by follistatin. Overall, these data show that BMP5 is a novel element of the BMP family that might play a fully paracrine role in rodent ovarian folliculogenesis. Abstract BMP5 is expressed by rat granulosa cells and exerts specific biological effects
ISSN:0006-3363
1529-7268
DOI:10.1095/biolreprod.105.043091