Pharmacokinetics of selamectin in dogs after topical application

Some pharmacokinetic parameters of selamectin were determined in male (n = 5) and female (n = 5) Beagle dogs following a topical application at a dose rate of 6 mg/kg. The plasma concentration versus time data for the drug were analysed using a one-compartment model. The maximum plasma concentration...

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Bibliographic Details
Published in:Veterinary research communications 2004-07, Vol.28 (5), p.407-413
Main Authors: Dupuy, J, Derlon, A L, Sutra, J F, Cadiergues, M C, Franc, M, Alvinerie, M
Format: Article
Language:English
Subjects:
Administration, Topical
Animals
Antiparasitic Agents - administration & dosage
Antiparasitic Agents - blood
Antiparasitic Agents - pharmacokinetics
Dogs - blood
Female
Half-Life
Ivermectin - administration & dosage
Ivermectin - analogs & derivatives
Ivermectin - blood
Ivermectin - pharmacokinetics
Life Sciences
Male
Metabolic Clearance Rate
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Summary:Some pharmacokinetic parameters of selamectin were determined in male (n = 5) and female (n = 5) Beagle dogs following a topical application at a dose rate of 6 mg/kg. The plasma concentration versus time data for the drug were analysed using a one-compartment model. The maximum plasma concentrations of 12.72 +/- 5.13 ng/ml for males and 22.65 +/- 11.95 ng/ml for females occurred around 5 days after administration. The area under the concentration-time curve (AUC) was 192.08 +/- 63.85 ng.day/ml for males and 370.97 +/- 146.87 ng.day/ml for females. The mean residence time was the same in males and females (12.55 days). This study reveals a sex-influence on the disposition of selamectin in the plasma of dogs, which implies that further information will be needed for correlation with efficacy studies in dogs.
ISSN:0165-7380
1573-7446
DOI:10.1023/B:VERC.0000034993.87007.f8