The influence of parasitism on the pharmacokinetics of moxidectin in lambs

Most pharmacokinetic studies on anthelmintic drugs have been performed on non-parasitized animals. However, it seems likely that the parasite burden could influence the deposition of such drugs. The pharmacokinetics of moxidectin administered orally and by subcutaneous injection was compared in lamb...

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Bibliographic Details
Published in:Parasitology research (1987) 2004-06, Vol.93 (2), p.121-126
Main Authors: LESPINE, Anne, SUTRA, Jean-Francois, DUPUY, Jacques, ALVINERIE, Michel, AUMONT, Gilles
Format: Article
Language:English
Subjects:
Animals
Anthelmintics - administration & dosage
Anthelmintics - pharmacokinetics
Area Under Curve
Biological and medical sciences
Fundamental and applied biological sciences. Psychology
General aspects
General aspects and techniques. Study of several systematic groups. Models
Haemonchiasis - drug therapy
Haemonchiasis - parasitology
Haemonchiasis - veterinary
Haemonchus - drug effects
Haemonchus - isolation & purification
Invertebrates
Life Sciences
Macrolides - administration & dosage
Macrolides - pharmacokinetics
Metabolic Clearance Rate
Microbiology and Parasitology
Parasite Egg Count
Sheep
Sheep Diseases - drug therapy
Sheep Diseases - parasitology
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Summary:Most pharmacokinetic studies on anthelmintic drugs have been performed on non-parasitized animals. However, it seems likely that the parasite burden could influence the deposition of such drugs. The pharmacokinetics of moxidectin administered orally and by subcutaneous injection was compared in lambs exposed to nematode infection and in parasite naive lambs. Plasma samples were analyzed for moxidectin over 40 days post-treatment. The main pharmacokinetic parameters calculated demonstrated a significant change in drug deposition in infected lambs when compared to controls. The area under the plasma concentration-time curve was decreased 54% and 46% by infection in the subcutaneous and oral groups, respectively. There was also a major decrease in the mean residence time in parasitized lambs. In parallel, the clearance of the drug was increased by infection. Thus, parasite infection dramatically influences the disposition of moxidectin in lambs. These results may contribute to determining a therapeutic strategy adapted to heavily infested animals.
ISSN:0932-0113
1432-1955
DOI:10.1007/s00436-004-1084-x