Quantitative risk assessment for Escherichia coli O157:H7 in frozen ground beef patties consumed by young children in French households

A quantitative risk assessment for Escherichia coli O157:H7 in frozen ground beef patties consumed by children under 10 years of age in French households was conducted by a national study group describing an outbreak which occurred in France in 2005. Our exposure assessment model incorporates result...

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Bibliographic Details
Published in:International journal of food microbiology 2008-11, Vol.128 (1), p.158-164
Main Authors: Delignette-Muller, M.L., Cornu, M.
Format: Article
Language:English
Subjects:
Age Factors
Animals
Bayes Theorem
Bayesian inference
Bayesian theory
Cattle
Child
child nutrition
Child, Preschool
children
Colony Count, Microbial
Cooking
Disease Outbreaks
Dose response
E. coli O157:H7
Escherichia coli
Escherichia coli Infections - epidemiology
Escherichia coli Infections - etiology
Escherichia coli Infections - microbiology
Escherichia coli O157 - growth & development
Escherichia coli O157:H7
exposure assessment
exposure models
exposure scenario
feeding frequency
feeding preferences
Female
Food Contamination - analysis
Food Handling - methods
food pathogens
food processing quality
food safety
Foodborne Diseases - epidemiology
France - epidemiology
Frozen Foods - microbiology
Frozen ground beef
ground beef
hemolytic uremic syndrome
Hemolytic-Uremic Syndrome - epidemiology
Hemolytic-Uremic Syndrome - etiology
Hemolytic-Uremic Syndrome - microbiology
Humans
Life Sciences
Male
Meat Products - microbiology
model food systems
national surveys
patties
predictive microbiology
probabilistic risk assessment
probability analysis
quantitative risk assessment
Risk Assessment
risk groups
serving size
statistical models
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Summary:A quantitative risk assessment for Escherichia coli O157:H7 in frozen ground beef patties consumed by children under 10 years of age in French households was conducted by a national study group describing an outbreak which occurred in France in 2005. Our exposure assessment model incorporates results from French surveys on consumption frequency of ground beef patties, serving size and consumption preference, microbial destruction experiments and microbial counts on patties sampled from the industrial batch which were responsible for the outbreak. Two different exposure models were proposed, respectively for children under the age of 5 and for children between 5 and 10 years. For each of these two age groups, a single-hit dose-response model was proposed to describe the probability of hemolytic and uremic syndrome (HUS) as a function of the ingested dose. For each group, the single parameter of this model was estimated by Bayesian inference, using the results of the exposure assessment and the epidemiological data collected during the outbreak. Results show that children under 5 years of age are roughly 5 times more susceptible to the pathogen than children over 5 years. Exposure and dose-response models were used in a scenario analysis in order to validate the use of the model and to propose appropriate guidelines in order to prevent new outbreaks. The impact of the cooking preference was evaluated, showing that only a well-done cooking notably reduces the HUS risk, without annulling it. For each age group, a relation between the mean individual HUS risk per serving and the contamination level in a ground beef batch was proposed, as a tool to help French risk managers.
ISSN:0168-1605
1879-3460
DOI:10.1016/j.ijfoodmicro.2008.05.040