Urinary citrulline in very low birth weight preterm infants receiving intravenous nutrition

As gut immaturity precludes full enteral feeding, very low birth weight (VLBW) preterm infants receive parenteral nutrition (PN) during the first few weeks of life. Weaning VLBW infants off PN, however, is a top priority since PN is associated with a high risk of complications. The decision making i...

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Bibliographic Details
Published in:British journal of nutrition 2012-10, Vol.108 (7), p.1150-1154
Main Authors: Bourdon, Aurélie, Rougé, Carole, Legrand, Arnaud, Des Robert, Clotilde, Piloquet, Hugues, Vodovar, Michel, Voyer, Marcel, Rozé, Jean-Christophe, Darmaun, Dominique
Format: Article
Language:English
Subjects:
Amino acids
Biological and medical sciences
Biomarkers - urine
Birth weight
Child Development
Citrulline - urine
Energy Intake
Feeding. Feeding behavior
France
Fundamental and applied biological sciences. Psychology
Gastrointestinal Tract - growth & development
Humans
Infant Nutritional Physiological Phenomena
Infant, Extremely Low Birth Weight
Infant, Newborn
Infant, Premature
Infant, Very Low Birth Weight
Intensive Care Units, Neonatal
Intravenous therapy
Life Sciences
Male
Multivariate Analysis
Nitrates - urine
Nitrites - urine
Nutrition research
Parenteral Nutrition
Parenteral Nutrition, Total
Pilot Projects
Premature birth
Vertebrates: anatomy and physiology, studies on body, several organs or systems
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Summary:As gut immaturity precludes full enteral feeding, very low birth weight (VLBW) preterm infants receive parenteral nutrition (PN) during the first few weeks of life. Weaning VLBW infants off PN, however, is a top priority since PN is associated with a high risk of complications. The decision making is purely empirical, as there is currently no suitable index of gastrointestinal (GI) maturity. Plasma citrulline concentration is considered an index of GI function in conditions such as short-bowel syndrome and coeliac disease in adults. To identify the factors determining urinary citrulline excretion, and determine whether urinary citrulline excretion could be used as a non-invasive index of GI tolerance to enteral feeding, nutritional intake and urinary citrulline were monitored bi-weekly in forty-seven preterm infants 
ISSN:0007-1145
1475-2662
DOI:10.1017/S0007114511006660