Early morphofunctional plasticity of microglia in response to acute lipopolysaccharide

Highlight • Our work confirmed that the concept of “resting” and “activated” microglia is misleading since microglia might present a high morpho-functional plasticity in vivo.

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Bibliographic Details
Published in:Brain, behavior, and immunity behavior, and immunity, 2013-11, Vol.34, p.151-158
Main Authors: Madore, C, Joffre, C, Delpech, J.C, De Smedt-Peyrusse, V, Aubert, A, Coste, L, Layé, S, Nadjar, A
Format: Article
Language:English
Subjects:
Allergy and Immunology
Animals
Cytokines - metabolism
Flow cytometry
Hippocampus - drug effects
Hippocampus - physiology
Inflammation
Inflammation - chemically induced
Life Sciences
Lipopolysaccharides - toxicity
M1/M2 phenotype
Male
Mice
Mice, Inbred C57BL
Microglia
Microglia - cytology
Microglia - drug effects
Microglia - physiology
Multiplex assay
Psychiatry
Two-photon imaging
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Description
Summary:Highlight • Our work confirmed that the concept of “resting” and “activated” microglia is misleading since microglia might present a high morpho-functional plasticity in vivo.
ISSN:0889-1591
1090-2139
DOI:10.1016/j.bbi.2013.08.008