Composition, and Antimicrobial and Remarkable Antiprotozoal Activities of the Essential Oil of Rhizomes of Aframomum sceptrum K. Schum. (Zingiberaceae)

The essential oil from the rhizomes of Aframomum sceptrum (Zingiberaceae) was analyzed by GC/MS, and its major constituents were found to be β‐pinene (12.7%), caryophyllene oxide (10.0%), and cyperene (6.0%). The oil was also evaluated for antimicrobial activities, in comparison with β‐pinene, caryo...

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Bibliographic Details
Published in:Chemistry & biodiversity 2011-04, Vol.8 (4), p.658-667
Main Authors: Cheikh-Ali, Zakaria, Adiko, Marcelline, Bouttier, Sylvie, Bories, Christian, Okpekon, Timothée, Poupon, Erwan, Champy, Pierre
Format: Article
Language:English
Subjects:
Aframomum sceptrum
Animals
Anti-Infective Agents - chemistry
Anti-Infective Agents - isolation & purification
Anti-Infective Agents - pharmacology
Antiprotozoal activity
Antiprotozoal Agents - chemistry
Antiprotozoal Agents - isolation & purification
Antiprotozoal Agents - pharmacology
Aspergillus
Bacillus subtilis
Bacteria - drug effects
Bacterial Infections - drug therapy
Bacteriostatic activity
Bridged Bicyclo Compounds - chemistry
Bridged Bicyclo Compounds - isolation & purification
Bridged Bicyclo Compounds - pharmacology
Candida albicans
Cattle
Essential oils
Fungi - drug effects
Fungicidal activity
Gas Chromatography-Mass Spectrometry
Humans
Life Sciences
Melaleuca alternifolia
Monoterpenes - chemistry
Monoterpenes - isolation & purification
Monoterpenes - pharmacology
Mycoses - drug therapy
Myrtaceae
Oils, Volatile - chemistry
Oils, Volatile - isolation & purification
Oils, Volatile - pharmacology
Plant Oils - chemistry
Plant Oils - isolation & purification
Plant Oils - pharmacology
Rhizome - chemistry
Sesquiterpenes - chemistry
Sesquiterpenes - isolation & purification
Sesquiterpenes - pharmacology
Staphylococcus aureus
Staphylococcus epidermidis
Trichomonas vaginalis
Trypanosoma brucei brucei
Trypanosoma brucei brucei - drug effects
Trypanosomiasis, Bovine - drug therapy
Zingiberaceae
Zingiberaceae - chemistry
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Summary:The essential oil from the rhizomes of Aframomum sceptrum (Zingiberaceae) was analyzed by GC/MS, and its major constituents were found to be β‐pinene (12.7%), caryophyllene oxide (10.0%), and cyperene (6.0%). The oil was also evaluated for antimicrobial activities, in comparison with β‐pinene, caryophyllene oxide, and the leaf essential oil of Melaleuca alternifolia (Myrtaceae). The A. sceptrum essential oil exhibited bacteriostatic activity against the Gram‐positive bacteria Bacillus subtilis, Staphylococcus epidermidis, and S. aureus, but not against Gram‐negative bacteria. Moreover, it showed mild fungicidal activity against Candida albicans and Aspergillus fumigates, and remarkable antiprotozoal activity against Trypanosoma brucei brucei (MLC of 1.51 μl/ml) and Trichomonas vaginalis (IC50 of 0.12±0.02 and MLC of 1.72 μl/ml).
ISSN:1612-1872
1612-1880
1612-1880
DOI:10.1002/cbdv.201000216