Contemporary assessment of the correlation between Bosniak classification and histological characteristics of surgically removed atypical renal cysts (UroCCR-12 study)

Purpose To evaluate and compare pathological characteristics of renal cysts Bosniak IIF, III and IV in light of recent histological classification. Patients and methods The French research network for kidney cancer UroCCR conducted a multicentre study on patients treated surgically for a renal cyst...

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Bibliographic Details
Published in:World journal of urology 2018-10, Vol.36 (10), p.1643-1649
Main Authors: Nouhaud, François-Xavier, Bernhard, Jean-Christophe, Bigot, Pierre, Khene, Zine-Eddine, Audenet, François, Lang, Herve, Bergerat, Sebastien, Fraisse, Guillaume, Grenier, Nicolas, Cornelis, François, Nedelcu, Cosmina, Béjar, Sofiane, Fromont-Hankard, Gaëlle, Allory, Yves, Lindner, Véronique, Verkarre, Virginie, Daniel, Laurent, Yacoub, Mokrane, Correas, Jean-Michel, Méjean, Arnaud, Rioux-Leclercq, Nathalie, Bensalah, Karim
Format: Article
Language:English
Subjects:
Aged
Cancer
Carcinoma, Renal Cell - classification
Carcinoma, Renal Cell - pathology
Carcinoma, Renal Cell - surgery
Clear cell-type renal cell carcinoma
Cysts
Cysts - classification
Cysts - pathology
Cysts - surgery
Female
Humans
Kidney cancer
Kidney Diseases, Cystic - classification
Kidney Diseases, Cystic - pathology
Kidney Diseases, Cystic - surgery
Kidney Neoplasms - classification
Kidney Neoplasms - pathology
Kidney Neoplasms - surgery
Life Sciences
Male
Medicine
Medicine & Public Health
Middle Aged
Neoplasm Recurrence, Local
Neoplasm Staging
Nephrology
Oncology
Original Article
Prognosis
Retrospective Studies
Tomography, X-Ray Computed
Tumors
Urology
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Summary:Purpose To evaluate and compare pathological characteristics of renal cysts Bosniak IIF, III and IV in light of recent histological classification. Patients and methods The French research network for kidney cancer UroCCR conducted a multicentre study on patients treated surgically for a renal cyst between 2007 and 2016. Independent radiological and centralized pathological reviews were performed for every patient. Pathological characteristics were compared to the Bosniak classification. Results Of a total 216 patients included, 175 (81.0%) tumours (90.9% of Bosniak IV, 69.8% of Bosniak III) were malignant or had a low malignant potential, with 60% of clear cell renal cell carcinoma (CCRCC), 24% of papillary RCC (PRCC) and 6.9% of multilocular cystic renal tumour of low malignant potential (MCRTLMP). Malignancies were mostly of low pT stage (86.4% of pT1–2), and low ISUP grade (68.0% of 1–2). Bosniak III cysts had a lower rate of CCRCC (46.7 vs. 67.3%), higher rate of PRCC (30 vs. 20.9%) and MCRTLMP (18.3 vs. 0.9%) compared to Bosniak IV ( p  
ISSN:0724-4983
1433-8726
DOI:10.1007/s00345-018-2307-6