Quinoline and phenanthroline preparation starting from glycerol via improved microwave-assisted modified Skraup reaction

An efficient “green” modified Skraup reaction in neat water was developed using inexpensive, abundant and environmentally-friendly glycerol under microwave irradiation conditions. Starting from aniline derivatives, various quinolines were obtained in 10–66% yields. The use of nitroaniline led to the...

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Bibliographic Details
Published in:RSC advances 2014, Vol.4 (41), p.21456-21464
Main Authors: Saggadi, Hanen, Luart, Denis, Thiebault, Nicolas, Polaert, Isabelle, Estel, Lionel, Len, C.
Format: Article
Language:English
Subjects:
Chemical and Process Engineering
Engineering Sciences
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Summary:An efficient “green” modified Skraup reaction in neat water was developed using inexpensive, abundant and environmentally-friendly glycerol under microwave irradiation conditions. Starting from aniline derivatives, various quinolines were obtained in 10–66% yields. The use of nitroaniline led to the corresponding phenanthrolines in 15–52% yields, respectively.
ISSN:2046-2069
2046-2069
DOI:10.1039/C4RA00758A