Birthweight difference of singletons conceived through in vitro fertilization with frozen versus fresh embryo transfer: An analysis of 5406 embryo transfers in a retrospective study 2013–2018

Perinatal risks after frozen embro transfer (FET) have been reassuring but some authors suggest that birthweights are higher after FET than after fresh embryo transfer (ET). The primary objective of this retrospective study, conducted in Clinique de la Sagesse, Rennes (France) from December 2013 to...

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Published in:Journal of gynecology obstetrics and human reproduction 2020-01, Vol.49 (1), p.101644-101644, Article 101644
Main Authors: Laval, Maude, Garlantézec, Ronan, Guivarc’h-Levêque, Anne
Format: Article
Language:English
Subjects:
Birthweight
Fresh embryo transfert
Frozen embryo transfer
Gynecology and obstetrics
Human health and pathology
In vitro fertilization
Life Sciences
Live birth
Santé publique et épidémiologie
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Summary:Perinatal risks after frozen embro transfer (FET) have been reassuring but some authors suggest that birthweights are higher after FET than after fresh embryo transfer (ET). The primary objective of this retrospective study, conducted in Clinique de la Sagesse, Rennes (France) from December 2013 to March 2017, was to determine whether a difference in birthweight exists between children conceived through in vitro fertilization (IVF) with frozen versus fresh ET. The secondary objective was to compare live birth rates after frozen versus fresh cycles. All couples undergoing IVF were included. Cycles with gamete donation and twin pregnancies were excluded. Hormone therapy was used in all embryo transfers. The main outcome measures were the child’s birthweight, mode of delivery, gestation length and sex, maternal characteristics, and IVF characteristics. The primary endpoint was birthweight. We studied 5406 embryo transfers and the 708 resulting singleton live births on which birthweight data were available. Mean birthweight was 3357g after frozen embryo transfer versus 3183g after fresh embryo transfer (p
ISSN:2468-7847
2468-8495
2468-7847
DOI:10.1016/j.jogoh.2019.101644