Palladium-Catalyzed Synthesis of Aryl and Heteroaryl Difluoromethylated Phosphonates

Abstract We report the palladium-catalyzed introduction of the di­fluoromethylposphonate unit onto aryl and heteroaryl iodides under mild conditions. Using the CuCF 2 PO(OEt) 2 species generated in situ, the method allows the functionalization of various otherwise reluctant substrates. In addition,...

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Bibliographic Details
Published in:Synthesis (Stuttgart) 2018-02, Vol.50 (4), p.778-784
Main Authors: Ivanova, Maria V., Besset, Tatiana, Pannecoucke, Xavier, Poisson, Thomas
Format: Article
Language:English
Subjects:
Chemical Sciences
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Summary:Abstract We report the palladium-catalyzed introduction of the di­fluoromethylposphonate unit onto aryl and heteroaryl iodides under mild conditions. Using the CuCF 2 PO(OEt) 2 species generated in situ, the method allows the functionalization of various otherwise reluctant substrates. In addition, this reaction permits the formation of CF 2 PO(OEt) 2 -containing heterocycles, an important class of compounds. This process broadens the current toolbox of methods available to construct CF 2 PO(OEt) 2 -containing molecules.
ISSN:0039-7881
1437-210X
DOI:10.1055/s-0036-1589140