Hyperprolactinemia in antipsychotic-naive patients with first-episode psychosis

Hyperprolactinemia is frequent in patients with schizophrenic psychoses. It is usually regarded as an adverse effect of antipsychotics but has recently also been shown in patients without antipsychotic medication. Our objective was to test whether hyperprolactinemia occurs in antipsychotic-naive fir...

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Bibliographic Details
Published in:Psychological medicine 2013-12, Vol.43 (12), p.2571-2582
Main Authors: Riecher-Rössler, A., Rybakowski, J. K., Pflueger, M. O., Beyrau, R., Kahn, R. S., Malik, P., Fleischhacker, W. W.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Adult and adolescent clinical studies
Antipsychotic drugs
Biological and medical sciences
Clinical trials
Clinical Trials as Topic
Endocrinopathies
Europe - epidemiology
Female
First time
Humans
Hyperprolactinemia - blood
Hyperprolactinemia - epidemiology
Hyperprolactinemia - etiology
Hypothalamus. Hypophysis. Epiphysis (diseases)
Life Sciences
Male
Medical sciences
Mental disorders
Neurons and Cognition
Neuropharmacology
Non tumoral diseases. Target tissue resistance. Benign neoplasms
Original Articles
Pharmacology. Drug treatments
Prolactin
Prolactin - blood
Psychiatry
Psycholeptics: tranquillizer, neuroleptic
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Psychopharmacology
Psychoses
Psychosis
Psychotic Disorders - complications
Psychotic Disorders - epidemiology
Psychotropic drugs
Schizophrenia
Sex Factors
Stress
Young Adult
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Summary:Hyperprolactinemia is frequent in patients with schizophrenic psychoses. It is usually regarded as an adverse effect of antipsychotics but has recently also been shown in patients without antipsychotic medication. Our objective was to test whether hyperprolactinemia occurs in antipsychotic-naive first-episode patients (FEPs). In the framework of the European First Episode Schizophrenia Trial (EUFEST), 249 out of 498 FEPs were eligible for this study, of whom 74 were antipsychotic naive. All patients were investigated regarding their serum prolactin levels with immunoassays standardized against the 3rd International Reference Standard 84/500. Twenty-nine (39%) of the 74 antipsychotic-naive patients showed hyperprolactinemia not explained by any other reason, 11 (50%) of 22 women and 18 (35%) of 52 men. Hyperprolactinemia may be present in patients with schizophrenic psychoses independent of antipsychotic medication. It might be stress induced. As enhanced prolactin can increase dopamine release through a feedback mechanism, this could contribute to explaining how stress can trigger the outbreak of psychosis.
ISSN:0033-2917
1469-8978
DOI:10.1017/S0033291713000226