Foam-Based Bionanocomposite Scaffold for Bone Tissue Engineering

The repair of large bone defects is a major clinical problem for which tissue engineering (association of a biomaterial and cells) constitutes a valuable alternative. In this domain, the architecture and the mechanical properties of the 3D scaffold aimed to support cells is of key importance to succ...

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Bibliographic Details
Published in:Key engineering materials 2017, Vol.758, p.145-149
Main Authors: Tourne-Peteilh, Corine, Girod Fullana, Sophie, Tourrette, Audrey, Quemeneur, Fany, Begu, Sylvie, Drouet, Christophe, Dupret-Bories, Agnès
Format: Article
Language:English
Subjects:
Apatite
Biocompatibility
Bioengineering
Biomaterials
Biomedical materials
Biopolymers
Calcium phosphates
Chemical Sciences
Engineering Sciences
Feasibility studies
Life Sciences
Material chemistry
Materials
Mechanical properties
Nucleation
Pectin
Scaffolds
Tissue engineering
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Summary:The repair of large bone defects is a major clinical problem for which tissue engineering (association of a biomaterial and cells) constitutes a valuable alternative. In this domain, the architecture and the mechanical properties of the 3D scaffold aimed to support cells is of key importance to succeed in bone reconstruction. In this study, we aim to design and evaluate a bionanocomposite foam-based scaffold, exhibiting all the desired biofunctional attributes of biocompatibility, bioactivity, osteoconduction/induction, combined with potential release properties. To perform this, 2 components have been associated: (i) a biopolymer, pectin, incorporating (ii) calcium phosphate nanoparticules to provide bone apatite nucleation sites, mechanical reinforcement, and to play the role of potential drug reservoir. The goal of this study was to determine the feasibility of obtention of such bionanocomposite by foam-templating, and to study the influence of mineral particules ratio on pectin foam and final scaffold 3D architecture and properties.
ISSN:1013-9826
1662-9795
1662-9795
DOI:10.4028/www.scientific.net/KEM.758.145