Risk factors for increased duration of untreated psychosis. Results from the FACE-SZ dataset

Reducing the duration of untreated psychosis (DUP) may improve the prognosis of schizophrenia. This study investigated the prevalence, and associated risk factors, of long DUP in a large, non-selected sample of community-dwelling schizophrenia patients (SZ). 478 community-dwelling stable SZ particip...

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Published in:Schizophrenia research 2018-05, Vol.195, p.529-533
Main Authors: Fond, G., Boyer, L., Andrianarisoa, M., Godin, O., Brunel, L., Bulzacka, E., Coulon, N., Llorca, P.M., Berna, F., Aouizerate, B., Capdevielle, D., D'Amato, T., Dubertret, C., Dubreucq, J., Faget, C., Gabayet, F., Mallet, J., Misdrahi, D., Rey, R., Richieri, R., Roux, P., Passerieux, C., Schandrin, A., Tronche, A.M., Vidailhet, P., Leboyer, M., Schürhoff, F., Blanc, O., Chereau-Boudet, I., Chesnoy-Servanin, G., Danion, J.M., Deloge, A., Delorme, C., Denizot, H., Dorey, J.M., Fluttaz, C., Fonteneau, S., Giraud-Baro, E., Hardy-Bayle, M.C., Lacelle, D., Lançon, C., Laouamri, H., Le Gloahec, T., Le Strat, Y., Metairie, E., Offerlin-Meyer, I., Peri, P., Pires, S., Portalier, C., Roman, C., Sebilleau, M., Schurhoff, F., Tessier, A., Urbach, M., Vaillant, F., Vehier, A., Vilà, E., Yazbek, H., Zinetti-Bertschy, A.
Format: Article
Language:English
Subjects:
Adult
Age at onset
Age of Onset
Antipsychotic
Cannabis
Cognitive science
Cognitive Sciences
Cohort Studies
Delayed Diagnosis
Duration of untreated psychosis
Educational Status
Female
France - epidemiology
Humans
Independent Living
Life Sciences
Male
Neurobiology
Neurons and Cognition
Neuroscience
Psychiatric Status Rating Scales
Psychology and behavior
Psychotic Disorders - diagnosis
Psychotic Disorders - epidemiology
Psychotic Disorders - psychology
Risk Factors
Schizophrenia
Schizophrenia - epidemiology
Schizophrenic Psychology
Sex Factors
Young Adult
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Summary:Reducing the duration of untreated psychosis (DUP) may improve the prognosis of schizophrenia. This study investigated the prevalence, and associated risk factors, of long DUP in a large, non-selected sample of community-dwelling schizophrenia patients (SZ). 478 community-dwelling stable SZ participants (122 women and 356 men; mean age 32.37±9.86years) were recruited between 2010 and 2016. The mean retrospective DUP was evaluated from both patient and family reports, as well as hospital/psychiatrists records. Long DUP was defined as >2years. The mean DUP was 1.5years. 80 participants (16.7%) had a DUP>2years. In multivariate analyses, after adjustment for sex, education level, history of childhood trauma and history of maternal schizophrenia or bipolar disorder, long DUP was associated with a younger age of illness onset (19.3±6.67years vs. 22.0±6.51years, adjusted odd ratio aOR=0.91, 95%CI [0.86; 0.97], p=0.003) and cannabis use disorder (20.0% vs. 10.3%, aOR=2.41, 95%CI [1.14–5.09], p=0.02). A high proportion of SZ patients still have a long DUP. The present results suggest that illness onset before age 19years and cannabis use are associated with long DUP in schizophrenia patients. Early psychosis detection programs should prioritize the targeting of these populations.
ISSN:0920-9964
1573-2509
DOI:10.1016/j.schres.2017.08.058