Brain Networks are Independently Modulated by Donepezil, Sleep, and Sleep Deprivation

Resting-state connectivity has been widely studied in the healthy and pathological brain. Less well-characterized are the brain networks altered during pharmacological interventions and their possible interaction with vigilance. In the hopes of finding new biomarkers which can be used to identify co...

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Bibliographic Details
Published in:Brain topography 2018-05, Vol.31 (3), p.380-391
Main Authors: Wirsich, Jonathan, Rey, Marc, Guye, Maxime, Bénar, Christian, Lanteaume, Laura, Ridley, Ben, Confort-Gouny, Sylviane, Cassé-Perrot, Catherine, Soulier, Elisabeth, Viout, Patrick, Rouby, Franck, Lefebvre, Marie-Noëlle, Audebert, Christine, Truillet, Romain, Jouve, Elisabeth, Payoux, Pierre, Bartrés-Faz, David, Bordet, Régis, Richardson, Jill C., Babiloni, Claudio, Rossini, Paolo Maria, Micallef, Joelle, Blin, Olivier, Ranjeva, Jean-Philippe
Format: Article
Language:English
Subjects:
Adult
Bioengineering
Biomedical and Life Sciences
Biomedicine
Brain - diagnostic imaging
Brain - drug effects
Brain - physiopathology
Brain Mapping
Cognitive ability
Computer Science
Cortex
Donepezil
Donepezil - pharmacology
EEG
Electroencephalography
Functional magnetic resonance imaging
Humans
Imaging
Life Sciences
Magnetic Resonance Imaging
Male
Medical Imaging
Medical innovations
Memantine
Nerve Net - diagnostic imaging
Nerve Net - drug effects
Nerve Net - physiopathology
Neural networks
Neurodegenerative diseases
Neurology
Neurosciences
Nootropic Agents - pharmacology
Original Paper
Psychiatry
Sleep - physiology
Sleep deprivation
Sleep Deprivation - diagnostic imaging
Sleep Deprivation - physiopathology
Statistical analysis
Vigilance
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Summary:Resting-state connectivity has been widely studied in the healthy and pathological brain. Less well-characterized are the brain networks altered during pharmacological interventions and their possible interaction with vigilance. In the hopes of finding new biomarkers which can be used to identify cortical activity and cognitive processes linked to the effects of drugs to treat neurodegenerative diseases such as Alzheimer’s disease, the analysis of networks altered by medication would be particularly interesting. Eleven healthy subjects were recruited in the context of the European Innovative Medicines Initiative ‘PharmaCog’. Each underwent five sessions of simultaneous EEG-fMRI in order to investigate the effects of donepezil and memantine before and after sleep deprivation (SD). The SD approach has been previously proposed as a model for cognitive impairment in healthy subjects. By applying network based statistics (NBS), we observed altered brain networks significantly linked to donepezil intake and sleep deprivation. Taking into account the sleep stages extracted from the EEG data we revealed that a network linked to sleep is interacting with sleep deprivation but not with medication intake. We successfully extracted the functional resting-state networks modified by donepezil intake, sleep and SD. We observed donepezil induced whole brain connectivity alterations forming a network separated from the changes induced by sleep and SD, a result which shows the utility of this approach to check for the validity of pharmacological resting-state analysis of the tested medications without the need of taking into account the subject specific vigilance.
ISSN:0896-0267
1573-6792
DOI:10.1007/s10548-017-0608-5