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Human papillomavirus does not play a role in the Barrett esophagus: a French cohort
Summary The role of human papillomavirus (HPV) in Barrett's esophagus (BE) has been examined but remains unclear. The purpose of the study is to dispute the connection between HPV and BE in a prospective case-control study. Biopsies were performed above and inside the Barrett's segment for...
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| Published in: | Diseases of the esophagus 2017-11, Vol.30 (11), p.1-7 |
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| container_end_page | 7 |
| container_issue | 11 |
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| container_title | Diseases of the esophagus |
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| creator | Brochard, C. Ducancelle, A. Pivert, A. Bodin, M. Ricard, A. Coron, E. Couffon, C. Dib, N. Luet, D. Musquer, N. Rhun, M. Le Bertrais, S. Michalak, S. Lunel-Fabiani, F. Cesbron-Metivier, E. Bosc, F.-X. Caroli |
| description | Summary
The role of human papillomavirus (HPV) in Barrett's esophagus (BE) has been examined but remains unclear. The purpose of the study is to dispute the connection between HPV and BE in a prospective case-control study. Biopsies were performed above and inside the Barrett's segment for BE patients and in the distal third of the esophagus for control patients for histological interpretation and for virological analysis. Biopsies for virological analysis were placed in a virus transport medium and immediately frozen in liquid nitrogen. Virological analysis involved real-time PCR using the SyBr® green protocol with modified SPF10 general primers. A total of 180 patients (119 control and 61 BE, respectively) were included. In BE patients, 31, 18, and 12 patients had, respectively, no dysplasia, low-grade dysplasia, and high grade dysplasia. Overall, nine were found to be HPV positive: five were control patients and four BE patients. HPV positive status was not associated with BE. No factors were associated with HPV, in particular the degree of BE dysplasia. HPV infection appears unlikely to be significant in the etiology of BE compared with control patients. (ClinicalTrials.gov, Number NCT02549053). |
| doi_str_mv | 10.1093/dote/dox088 |
| format | article |
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The role of human papillomavirus (HPV) in Barrett's esophagus (BE) has been examined but remains unclear. The purpose of the study is to dispute the connection between HPV and BE in a prospective case-control study. Biopsies were performed above and inside the Barrett's segment for BE patients and in the distal third of the esophagus for control patients for histological interpretation and for virological analysis. Biopsies for virological analysis were placed in a virus transport medium and immediately frozen in liquid nitrogen. Virological analysis involved real-time PCR using the SyBr® green protocol with modified SPF10 general primers. A total of 180 patients (119 control and 61 BE, respectively) were included. In BE patients, 31, 18, and 12 patients had, respectively, no dysplasia, low-grade dysplasia, and high grade dysplasia. Overall, nine were found to be HPV positive: five were control patients and four BE patients. HPV positive status was not associated with BE. No factors were associated with HPV, in particular the degree of BE dysplasia. HPV infection appears unlikely to be significant in the etiology of BE compared with control patients. (ClinicalTrials.gov, Number NCT02549053).</description><identifier>ISSN: 1120-8694</identifier><identifier>EISSN: 1442-2050</identifier><identifier>DOI: 10.1093/dote/dox088</identifier><identifier>PMID: 28881904</identifier><language>eng</language><publisher>United States: Oxford University Press</publisher><subject>Aged ; Barrett Esophagus - pathology ; Barrett Esophagus - virology ; Biopsy ; Cancer ; Case-Control Studies ; Endocrinology and metabolism ; Esophagus - pathology ; Esophagus - virology ; Female ; Food and Nutrition ; France ; Human health and pathology ; Humans ; Hyperplasia - virology ; Life Sciences ; Male ; Middle Aged ; Papillomaviridae ; Papillomavirus Infections - complications ; Papillomavirus Infections - virology ; Prospective Studies ; Real-Time Polymerase Chain Reaction</subject><ispartof>Diseases of the esophagus, 2017-11, Vol.30 (11), p.1-7</ispartof><rights>The Authors 2017. Published by Oxford University Press on behalf of International Society for Diseases of the Esophagus. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com 2017</rights><rights>The Authors 2017. Published by Oxford University Press on behalf of International Society for Diseases of the Esophagus. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c312t-4dfbd17c9c34c28ee1906ac0cc79da63831578010a7f544db7fb9cab792cdb433</cites><orcidid>0000-0001-7388-0916</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,315,786,790,891,1591,27957,27958</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28881904$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://univ-rennes.hal.science/hal-01618033$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Brochard, C.</creatorcontrib><creatorcontrib>Ducancelle, A.</creatorcontrib><creatorcontrib>Pivert, A.</creatorcontrib><creatorcontrib>Bodin, M.</creatorcontrib><creatorcontrib>Ricard, A.</creatorcontrib><creatorcontrib>Coron, E.</creatorcontrib><creatorcontrib>Couffon, C.</creatorcontrib><creatorcontrib>Dib, N.</creatorcontrib><creatorcontrib>Luet, D.</creatorcontrib><creatorcontrib>Musquer, N.</creatorcontrib><creatorcontrib>Rhun, M. Le</creatorcontrib><creatorcontrib>Bertrais, S.</creatorcontrib><creatorcontrib>Michalak, S.</creatorcontrib><creatorcontrib>Lunel-Fabiani, F.</creatorcontrib><creatorcontrib>Cesbron-Metivier, E.</creatorcontrib><creatorcontrib>Bosc, F.-X. Caroli</creatorcontrib><title>Human papillomavirus does not play a role in the Barrett esophagus: a French cohort</title><title>Diseases of the esophagus</title><addtitle>Dis Esophagus</addtitle><description>Summary
The role of human papillomavirus (HPV) in Barrett's esophagus (BE) has been examined but remains unclear. The purpose of the study is to dispute the connection between HPV and BE in a prospective case-control study. Biopsies were performed above and inside the Barrett's segment for BE patients and in the distal third of the esophagus for control patients for histological interpretation and for virological analysis. Biopsies for virological analysis were placed in a virus transport medium and immediately frozen in liquid nitrogen. Virological analysis involved real-time PCR using the SyBr® green protocol with modified SPF10 general primers. A total of 180 patients (119 control and 61 BE, respectively) were included. In BE patients, 31, 18, and 12 patients had, respectively, no dysplasia, low-grade dysplasia, and high grade dysplasia. Overall, nine were found to be HPV positive: five were control patients and four BE patients. HPV positive status was not associated with BE. No factors were associated with HPV, in particular the degree of BE dysplasia. HPV infection appears unlikely to be significant in the etiology of BE compared with control patients. (ClinicalTrials.gov, Number NCT02549053).</description><subject>Aged</subject><subject>Barrett Esophagus - pathology</subject><subject>Barrett Esophagus - virology</subject><subject>Biopsy</subject><subject>Cancer</subject><subject>Case-Control Studies</subject><subject>Endocrinology and metabolism</subject><subject>Esophagus - pathology</subject><subject>Esophagus - virology</subject><subject>Female</subject><subject>Food and Nutrition</subject><subject>France</subject><subject>Human health and pathology</subject><subject>Humans</subject><subject>Hyperplasia - virology</subject><subject>Life Sciences</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Papillomaviridae</subject><subject>Papillomavirus Infections - complications</subject><subject>Papillomavirus Infections - virology</subject><subject>Prospective Studies</subject><subject>Real-Time Polymerase Chain Reaction</subject><issn>1120-8694</issn><issn>1442-2050</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><recordid>eNp9kEFLwzAYQIMoTqcn75KTKFJNmrRJvc3hnDDwoJ5Dmqa20jY1SYf792Z07uglX_h4PD4eABcY3WGUkfvCeB2eH8T5ATjBlMZRjBJ0GP44RhFPMzoBp859IYQZSfkxmMScc5whegLelkMrO9jLvm4a08p1bQcHC6Md7IyHfSM3UEJrGg3rDvpKw0dprfYeamf6Sn4O7iEAC6s7VUFlKmP9GTgqZeP0-W5Owcfi6X2-jFavzy_z2SpSBMc-okWZF5ipTBGqYq51uCiVCinFskKmhBOcMI4wkqxMKC1yVuaZkjnLYlXklJApuBm9lWxEb-tW2o0wshbL2UpsdwinmCNC1jiw1yPbW_M9aOdFWzulm0Z22gxO4IywBPMQLKC3I6qscc7qcu_GSGyLi21xMRYP9OVOPOStLvbsX-IAXI2AGfp_Tb-PgInQ</recordid><startdate>20171101</startdate><enddate>20171101</enddate><creator>Brochard, C.</creator><creator>Ducancelle, A.</creator><creator>Pivert, A.</creator><creator>Bodin, M.</creator><creator>Ricard, A.</creator><creator>Coron, E.</creator><creator>Couffon, C.</creator><creator>Dib, N.</creator><creator>Luet, D.</creator><creator>Musquer, N.</creator><creator>Rhun, M. Le</creator><creator>Bertrais, S.</creator><creator>Michalak, S.</creator><creator>Lunel-Fabiani, F.</creator><creator>Cesbron-Metivier, E.</creator><creator>Bosc, F.-X. Caroli</creator><general>Oxford University Press</general><general>Wiley</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>1XC</scope><orcidid>https://orcid.org/0000-0001-7388-0916</orcidid></search><sort><creationdate>20171101</creationdate><title>Human papillomavirus does not play a role in the Barrett esophagus: a French cohort</title><author>Brochard, C. ; Ducancelle, A. ; Pivert, A. ; Bodin, M. ; Ricard, A. ; Coron, E. ; Couffon, C. ; Dib, N. ; Luet, D. ; Musquer, N. ; Rhun, M. Le ; Bertrais, S. ; Michalak, S. ; Lunel-Fabiani, F. ; Cesbron-Metivier, E. ; Bosc, F.-X. Caroli</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c312t-4dfbd17c9c34c28ee1906ac0cc79da63831578010a7f544db7fb9cab792cdb433</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Aged</topic><topic>Barrett Esophagus - pathology</topic><topic>Barrett Esophagus - virology</topic><topic>Biopsy</topic><topic>Cancer</topic><topic>Case-Control Studies</topic><topic>Endocrinology and metabolism</topic><topic>Esophagus - pathology</topic><topic>Esophagus - virology</topic><topic>Female</topic><topic>Food and Nutrition</topic><topic>France</topic><topic>Human health and pathology</topic><topic>Humans</topic><topic>Hyperplasia - virology</topic><topic>Life Sciences</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Papillomaviridae</topic><topic>Papillomavirus Infections - complications</topic><topic>Papillomavirus Infections - virology</topic><topic>Prospective Studies</topic><topic>Real-Time Polymerase Chain Reaction</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Brochard, C.</creatorcontrib><creatorcontrib>Ducancelle, A.</creatorcontrib><creatorcontrib>Pivert, A.</creatorcontrib><creatorcontrib>Bodin, M.</creatorcontrib><creatorcontrib>Ricard, A.</creatorcontrib><creatorcontrib>Coron, E.</creatorcontrib><creatorcontrib>Couffon, C.</creatorcontrib><creatorcontrib>Dib, N.</creatorcontrib><creatorcontrib>Luet, D.</creatorcontrib><creatorcontrib>Musquer, N.</creatorcontrib><creatorcontrib>Rhun, M. Le</creatorcontrib><creatorcontrib>Bertrais, S.</creatorcontrib><creatorcontrib>Michalak, S.</creatorcontrib><creatorcontrib>Lunel-Fabiani, F.</creatorcontrib><creatorcontrib>Cesbron-Metivier, E.</creatorcontrib><creatorcontrib>Bosc, F.-X. Caroli</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><jtitle>Diseases of the esophagus</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Brochard, C.</au><au>Ducancelle, A.</au><au>Pivert, A.</au><au>Bodin, M.</au><au>Ricard, A.</au><au>Coron, E.</au><au>Couffon, C.</au><au>Dib, N.</au><au>Luet, D.</au><au>Musquer, N.</au><au>Rhun, M. Le</au><au>Bertrais, S.</au><au>Michalak, S.</au><au>Lunel-Fabiani, F.</au><au>Cesbron-Metivier, E.</au><au>Bosc, F.-X. Caroli</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Human papillomavirus does not play a role in the Barrett esophagus: a French cohort</atitle><jtitle>Diseases of the esophagus</jtitle><addtitle>Dis Esophagus</addtitle><date>2017-11-01</date><risdate>2017</risdate><volume>30</volume><issue>11</issue><spage>1</spage><epage>7</epage><pages>1-7</pages><issn>1120-8694</issn><eissn>1442-2050</eissn><notes>ObjectType-Article-1</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-2</notes><notes>content type line 23</notes><abstract>Summary
The role of human papillomavirus (HPV) in Barrett's esophagus (BE) has been examined but remains unclear. The purpose of the study is to dispute the connection between HPV and BE in a prospective case-control study. Biopsies were performed above and inside the Barrett's segment for BE patients and in the distal third of the esophagus for control patients for histological interpretation and for virological analysis. Biopsies for virological analysis were placed in a virus transport medium and immediately frozen in liquid nitrogen. Virological analysis involved real-time PCR using the SyBr® green protocol with modified SPF10 general primers. A total of 180 patients (119 control and 61 BE, respectively) were included. In BE patients, 31, 18, and 12 patients had, respectively, no dysplasia, low-grade dysplasia, and high grade dysplasia. Overall, nine were found to be HPV positive: five were control patients and four BE patients. HPV positive status was not associated with BE. No factors were associated with HPV, in particular the degree of BE dysplasia. HPV infection appears unlikely to be significant in the etiology of BE compared with control patients. (ClinicalTrials.gov, Number NCT02549053).</abstract><cop>United States</cop><pub>Oxford University Press</pub><pmid>28881904</pmid><doi>10.1093/dote/dox088</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0001-7388-0916</orcidid></addata></record> |
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| ispartof | Diseases of the esophagus, 2017-11, Vol.30 (11), p.1-7 |
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| subjects | Aged Barrett Esophagus - pathology Barrett Esophagus - virology Biopsy Cancer Case-Control Studies Endocrinology and metabolism Esophagus - pathology Esophagus - virology Female Food and Nutrition France Human health and pathology Humans Hyperplasia - virology Life Sciences Male Middle Aged Papillomaviridae Papillomavirus Infections - complications Papillomavirus Infections - virology Prospective Studies Real-Time Polymerase Chain Reaction |
| title | Human papillomavirus does not play a role in the Barrett esophagus: a French cohort |
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