Human papillomavirus does not play a role in the Barrett esophagus: a French cohort

Summary The role of human papillomavirus (HPV) in Barrett's esophagus (BE) has been examined but remains unclear. The purpose of the study is to dispute the connection between HPV and BE in a prospective case-control study. Biopsies were performed above and inside the Barrett's segment for...

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Bibliographic Details
Published in:Diseases of the esophagus 2017-11, Vol.30 (11), p.1-7
Main Authors: Brochard, C., Ducancelle, A., Pivert, A., Bodin, M., Ricard, A., Coron, E., Couffon, C., Dib, N., Luet, D., Musquer, N., Rhun, M. Le, Bertrais, S., Michalak, S., Lunel-Fabiani, F., Cesbron-Metivier, E., Bosc, F.-X. Caroli
Format: Article
Language:English
Subjects:
Aged
Barrett Esophagus - pathology
Barrett Esophagus - virology
Biopsy
Cancer
Case-Control Studies
Endocrinology and metabolism
Esophagus - pathology
Esophagus - virology
Female
Food and Nutrition
France
Human health and pathology
Humans
Hyperplasia - virology
Life Sciences
Male
Middle Aged
Papillomaviridae
Papillomavirus Infections - complications
Papillomavirus Infections - virology
Prospective Studies
Real-Time Polymerase Chain Reaction
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Summary:Summary The role of human papillomavirus (HPV) in Barrett's esophagus (BE) has been examined but remains unclear. The purpose of the study is to dispute the connection between HPV and BE in a prospective case-control study. Biopsies were performed above and inside the Barrett's segment for BE patients and in the distal third of the esophagus for control patients for histological interpretation and for virological analysis. Biopsies for virological analysis were placed in a virus transport medium and immediately frozen in liquid nitrogen. Virological analysis involved real-time PCR using the SyBr® green protocol with modified SPF10 general primers. A total of 180 patients (119 control and 61 BE, respectively) were included. In BE patients, 31, 18, and 12 patients had, respectively, no dysplasia, low-grade dysplasia, and high grade dysplasia. Overall, nine were found to be HPV positive: five were control patients and four BE patients. HPV positive status was not associated with BE. No factors were associated with HPV, in particular the degree of BE dysplasia. HPV infection appears unlikely to be significant in the etiology of BE compared with control patients. (ClinicalTrials.gov, Number NCT02549053).
ISSN:1120-8694
1442-2050
DOI:10.1093/dote/dox088