Photosensitized cleavage of some olefins as potential linkers to be used in drug delivery

[Display omitted] •Photo-cleavage of olefins as potential linkers in drug complexes is reported.•The rate constants for singlet oxygen quenching by studied olefins are determined.•The photoproducts are investigated by FTIR in combination with DFT calculations. A study of photosensitized cleavage of...

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Bibliographic Details
Published in:Applied surface science 2017-09, Vol.417, p.136-142
Main Authors: Dinache, Andra, Smarandache, Adriana, Simon, Agota, Nastasa, Viorel, Tozar, Tatiana, Pascu, Alexandru, Enescu, Mironel, Khatyr, Abderrahim, Sima, Felix, Pascu, Mihail - Lucian, Staicu, Angela
Format: Article
Language:English
Subjects:
Astrophysics
FTIR
Linkers
Olefins
Photosensitizer
Physics
Quenching rate
Singlet oxygen
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Summary:[Display omitted] •Photo-cleavage of olefins as potential linkers in drug complexes is reported.•The rate constants for singlet oxygen quenching by studied olefins are determined.•The photoproducts are investigated by FTIR in combination with DFT calculations. A study of photosensitized cleavage of different olefins as potential linkers for drug carrier complexes is reported. The role of singlet oxygen and the kinetic rates for light induced reactions were estimated by time-resolved measurements of singlet oxygen phosphorescence (at 1270nm) obtained via 532nm pulse laser excitation of a photosensitizer. The mixture of each studied olefin with verteporfin (used as photosensitizer) were exposed to low energy visible radiation. The rate constants for singlet oxygen quenching by studied olefins were determined. The irradiated solutions were investigated by FTIR spectroscopy and potential photoproducts were suggested. The experimental results were compared with simulations made by DFT method.
ISSN:0169-4332
1873-5584
DOI:10.1016/j.apsusc.2017.03.177