Utilisation of water soluble iridium catalysts for signal amplification by reversible exchange

The catalytic hyperpolarisation of pyridine, 3-hydroxypyridine and oxazole by the Signal Amplification By Reversible Exchange (SABRE) process is achieved by a series of water soluble iridium phosphine and N-heterocyclic carbene dihydride complexes. While the efficiency of the SABRE process in methan...

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Bibliographic Details
Published in:Dalton transactions : an international journal of inorganic chemistry 2015-05, Vol.44 (17), p.7870-7880
Main Authors: Fekete, M, Gibard, C, Dear, G J, Green, G G R, Hooper, A J J, Roberts, A D, Cisnetti, F, Duckett, S B
Format: Article
Language:English
Subjects:
Amplification
Catalysis
Catalysts
Chemical Sciences
Exchange
Iridium
Phosphines
Pyridines
Solubility
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Summary:The catalytic hyperpolarisation of pyridine, 3-hydroxypyridine and oxazole by the Signal Amplification By Reversible Exchange (SABRE) process is achieved by a series of water soluble iridium phosphine and N-heterocyclic carbene dihydride complexes. While the efficiency of the SABRE process in methanol-d4 solution or ethanol-d6 solution is high, with over 400-fold (1)H polarisation of pyridine being produced by [Ir(H)2(NCMe)(py)(IMes)(monosulfonated-triphenylphosphine)]BF4, changing to a D2O or a D2O-ethanol solvent mixture leads to dramatically reduced activity which is rationalised in terms of low H2 solubility.
ISSN:1477-9226
1477-9234
DOI:10.1039/c5dt00311c