Molecular epidemiology of OXA-48-producing Klebsiella pneumoniae in France

We characterized 53 OXA-48-producing Klebsiella pneumoniae (OXA-48-Kp) isolated between 2011 and 2013 in 21 French hospitals. All the isolates were genotyped using MLST and PFGE and the population structure of the species was determined by a nucleotide-based analysis of the entire K. pneumoniae MLST...

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Bibliographic Details
Published in:Clinical microbiology and infection 2014-12, Vol.20 (12), p.O1121-O1123
Main Authors: Liapis, E., Pantel, A., Robert, J., Nicolas-Chanoine, M.-H., Cavalié, L., van der Mee-Marquet, N., de Champs, C., Aissa, N., Eloy, C., Blanc, V., Guyeux, C., Hocquet, D., Lavigne, J.-P., Bertrand, X., On behalf of ONERBA
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - pharmacology
beta-Lactamases - secretion
Electrophoresis, Gel, Pulsed-Field
France - epidemiology
Genotype
Hospitals
Humans
Imipenem - pharmacology
Klebsiella Infections - epidemiology
Klebsiella Infections - microbiology
Klebsiella pneumoniae
Klebsiella pneumoniae - classification
Klebsiella pneumoniae - enzymology
Klebsiella pneumoniae - genetics
Klebsiella pneumoniae - isolation & purification
Life Sciences
Microbiology and Parasitology
Molecular Epidemiology
Multidrug resistance
Multilocus Sequence Typing
phylogenetic analysis
Thienamycins - pharmacology
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Summary:We characterized 53 OXA-48-producing Klebsiella pneumoniae (OXA-48-Kp) isolated between 2011 and 2013 in 21 French hospitals. All the isolates were genotyped using MLST and PFGE and the population structure of the species was determined by a nucleotide-based analysis of the entire K. pneumoniae MLST database. Most of the OXA-48-Kp isolates also produced CTX-M-15 and remained susceptible to imipenem and meropenem. The isolates were distributed into 20 STs, of which five were dominant (ST15, ST101, ST147, ST395 and ST405). All the OXA-48-Kp clustered in the major clade of K. pneumoniae KpI.
ISSN:1198-743X
1469-0691
DOI:10.1111/1469-0691.12727