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Photoactivation of gold nanoparticles for glioma treatment
Abstract Radiosensitization efficacy of gold nanoparticles (AuNPs) with low energy radiations (88 keV) was evaluated in vitro and in vivo on rats bearing glioma. In vitro, a significant dose-enhancement factor was measured by clonogenic assays after irradiation with synchrotron radiation of F98 glio...
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| Published in: | Nanomedicine 2013-10, Vol.9 (7), p.1089-1097 |
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| container_title | Nanomedicine |
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| creator | Bobyk, Laure, PhD Edouard, Magali, PhD Deman, Pierre, PhD Vautrin, Mathias, PhD Pernet-Gallay, Karin, PhD Delaroche, Julie Adam, Jean-François, PhD Estève, François, MD, PhD Ravanat, Jean-Luc, PhD Elleaume, Hélène, PhD |
| description | Abstract Radiosensitization efficacy of gold nanoparticles (AuNPs) with low energy radiations (88 keV) was evaluated in vitro and in vivo on rats bearing glioma. In vitro, a significant dose-enhancement factor was measured by clonogenic assays after irradiation with synchrotron radiation of F98 glioma cells in presence of AuNPs (1.9 and 15 nm in diameter). In vivo, 1.9 nm nanoparticles were found to be toxic following intracerebral delivery in rats bearing glioma, whether no toxicity was observed using 15 nm nanoparticles at the same concentration (50 mg/mL). The therapeutic efficacy of gold photoactivation was determined by irradiating the animals after intracerebral infusion of AuNPs. Survival of rats that had received the combination of treatments (AuNPs: 50 mg/mL, 15 Gy) was significantly increased in comparison with the survival of rats that had received irradiation alone. In conclusion, this experimental approach is promising and further studies are foreseen for improving its therapeutic efficacy. From the Clinical Editor These investigators report that gold nanoparticles of the correct size can be used to enhance the effects of irradiation in the context of a glioma model. Since many of the glioma varieties are currently incurable, this or similar approaches may find their way to clinical trials in the near future. |
| doi_str_mv | 10.1016/j.nano.2013.04.007 |
| format | article |
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In vitro, a significant dose-enhancement factor was measured by clonogenic assays after irradiation with synchrotron radiation of F98 glioma cells in presence of AuNPs (1.9 and 15 nm in diameter). In vivo, 1.9 nm nanoparticles were found to be toxic following intracerebral delivery in rats bearing glioma, whether no toxicity was observed using 15 nm nanoparticles at the same concentration (50 mg/mL). The therapeutic efficacy of gold photoactivation was determined by irradiating the animals after intracerebral infusion of AuNPs. Survival of rats that had received the combination of treatments (AuNPs: 50 mg/mL, 15 Gy) was significantly increased in comparison with the survival of rats that had received irradiation alone. In conclusion, this experimental approach is promising and further studies are foreseen for improving its therapeutic efficacy. From the Clinical Editor These investigators report that gold nanoparticles of the correct size can be used to enhance the effects of irradiation in the context of a glioma model. Since many of the glioma varieties are currently incurable, this or similar approaches may find their way to clinical trials in the near future.</description><identifier>ISSN: 1549-9634</identifier><identifier>EISSN: 1549-9642</identifier><identifier>DOI: 10.1016/j.nano.2013.04.007</identifier><identifier>PMID: 23643529</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Animals ; Brain - pathology ; Brain - radiation effects ; Brain - ultrastructure ; Brain Neoplasms - diagnostic imaging ; Brain Neoplasms - pathology ; Brain Neoplasms - radiotherapy ; Brain tumors ; Cancer ; Cell Line, Tumor ; Cell Survival - radiation effects ; Drug Administration Routes ; Glioma ; Glioma - diagnostic imaging ; Glioma - pathology ; Glioma - radiotherapy ; Gold - radiation effects ; Gold - toxicity ; Gold nanoparticles ; Internal Medicine ; Kaplan-Meier Estimate ; Life Sciences ; Light ; Male ; Medical Physics ; Metal Nanoparticles - radiation effects ; Metal Nanoparticles - toxicity ; Neostriatum - drug effects ; Neostriatum - pathology ; Photoactivation ; Physics ; Radiography ; Rats ; Rats, Inbred F344 ; Subcellular Fractions - metabolism ; Subcellular Fractions - radiation effects ; Synchrotron radiation ; X-Rays</subject><ispartof>Nanomedicine, 2013-10, Vol.9 (7), p.1089-1097</ispartof><rights>Elsevier Inc.</rights><rights>2013 Elsevier Inc.</rights><rights>Copyright © 2013 Elsevier Inc. All rights reserved.</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c544t-8eeddc654a0a0ec59534fab3a13ca05deb32cf55d8521e5ea841f952a3eb99463</citedby><cites>FETCH-LOGICAL-c544t-8eeddc654a0a0ec59534fab3a13ca05deb32cf55d8521e5ea841f952a3eb99463</cites><orcidid>0000-0002-3991-9503 ; 0000-0003-3468-3316</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,315,786,790,891,27957,27958</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23643529$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.science/hal-00850657$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Bobyk, Laure, PhD</creatorcontrib><creatorcontrib>Edouard, Magali, PhD</creatorcontrib><creatorcontrib>Deman, Pierre, PhD</creatorcontrib><creatorcontrib>Vautrin, Mathias, PhD</creatorcontrib><creatorcontrib>Pernet-Gallay, Karin, PhD</creatorcontrib><creatorcontrib>Delaroche, Julie</creatorcontrib><creatorcontrib>Adam, Jean-François, PhD</creatorcontrib><creatorcontrib>Estève, François, MD, PhD</creatorcontrib><creatorcontrib>Ravanat, Jean-Luc, PhD</creatorcontrib><creatorcontrib>Elleaume, Hélène, PhD</creatorcontrib><title>Photoactivation of gold nanoparticles for glioma treatment</title><title>Nanomedicine</title><addtitle>Nanomedicine</addtitle><description>Abstract Radiosensitization efficacy of gold nanoparticles (AuNPs) with low energy radiations (88 keV) was evaluated in vitro and in vivo on rats bearing glioma. In vitro, a significant dose-enhancement factor was measured by clonogenic assays after irradiation with synchrotron radiation of F98 glioma cells in presence of AuNPs (1.9 and 15 nm in diameter). In vivo, 1.9 nm nanoparticles were found to be toxic following intracerebral delivery in rats bearing glioma, whether no toxicity was observed using 15 nm nanoparticles at the same concentration (50 mg/mL). The therapeutic efficacy of gold photoactivation was determined by irradiating the animals after intracerebral infusion of AuNPs. Survival of rats that had received the combination of treatments (AuNPs: 50 mg/mL, 15 Gy) was significantly increased in comparison with the survival of rats that had received irradiation alone. In conclusion, this experimental approach is promising and further studies are foreseen for improving its therapeutic efficacy. From the Clinical Editor These investigators report that gold nanoparticles of the correct size can be used to enhance the effects of irradiation in the context of a glioma model. Since many of the glioma varieties are currently incurable, this or similar approaches may find their way to clinical trials in the near future.</description><subject>Animals</subject><subject>Brain - pathology</subject><subject>Brain - radiation effects</subject><subject>Brain - ultrastructure</subject><subject>Brain Neoplasms - diagnostic imaging</subject><subject>Brain Neoplasms - pathology</subject><subject>Brain Neoplasms - radiotherapy</subject><subject>Brain tumors</subject><subject>Cancer</subject><subject>Cell Line, Tumor</subject><subject>Cell Survival - radiation effects</subject><subject>Drug Administration Routes</subject><subject>Glioma</subject><subject>Glioma - diagnostic imaging</subject><subject>Glioma - pathology</subject><subject>Glioma - radiotherapy</subject><subject>Gold - radiation effects</subject><subject>Gold - toxicity</subject><subject>Gold nanoparticles</subject><subject>Internal Medicine</subject><subject>Kaplan-Meier Estimate</subject><subject>Life Sciences</subject><subject>Light</subject><subject>Male</subject><subject>Medical Physics</subject><subject>Metal Nanoparticles - radiation effects</subject><subject>Metal Nanoparticles - toxicity</subject><subject>Neostriatum - drug effects</subject><subject>Neostriatum - pathology</subject><subject>Photoactivation</subject><subject>Physics</subject><subject>Radiography</subject><subject>Rats</subject><subject>Rats, Inbred F344</subject><subject>Subcellular Fractions - metabolism</subject><subject>Subcellular Fractions - radiation effects</subject><subject>Synchrotron radiation</subject><subject>X-Rays</subject><issn>1549-9634</issn><issn>1549-9642</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><recordid>eNp9kU1rFEEQhhtRzIf-AQ8yRz3sWP01sy0ihGCMsGAgem5qe2qSXnum1-7ehfx7Z9i4hxxy6qJ53rfgKcbecag58ObTph5xjLUALmtQNUD7gp1yrczCNEq8PM5SnbCznDcAsgUwr9mJkI2SWphT9vnmPpaIrvg9Fh_HKvbVXQxdNVdvMRXvAuWqj6m6Cz4OWJVEWAYayxv2qseQ6e3je85-X337dXm9WP38_uPyYrVwWqmyWBJ1nWu0QkAgp42Wqse1RC4dgu5oLYXrte6WWnDShEvFe6MFSloboxp5zj4eeu8x2G3yA6YHG9Hb64uVnf8Alhoa3e75xH44sNsU_-4oFzv47CgEHCnusuV6stSKtpETKg6oSzHnRP2xm4Od_dqNnSXY2a8FNa1pp9D7x_7deqDuGPkvdAK-HACajOw9JZudp9FR5xO5Yrvon-__-iTugh-9w_CHHihv4i6Nk2vLbRYW7O184fnAXALw1gj5DxKUoC4</recordid><startdate>20131001</startdate><enddate>20131001</enddate><creator>Bobyk, Laure, PhD</creator><creator>Edouard, Magali, PhD</creator><creator>Deman, Pierre, PhD</creator><creator>Vautrin, Mathias, PhD</creator><creator>Pernet-Gallay, Karin, PhD</creator><creator>Delaroche, Julie</creator><creator>Adam, Jean-François, PhD</creator><creator>Estève, François, MD, PhD</creator><creator>Ravanat, Jean-Luc, PhD</creator><creator>Elleaume, Hélène, PhD</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>1XC</scope><orcidid>https://orcid.org/0000-0002-3991-9503</orcidid><orcidid>https://orcid.org/0000-0003-3468-3316</orcidid></search><sort><creationdate>20131001</creationdate><title>Photoactivation of gold nanoparticles for glioma treatment</title><author>Bobyk, Laure, PhD ; Edouard, Magali, PhD ; Deman, Pierre, PhD ; Vautrin, Mathias, PhD ; Pernet-Gallay, Karin, PhD ; Delaroche, Julie ; Adam, Jean-François, PhD ; Estève, François, MD, PhD ; Ravanat, Jean-Luc, PhD ; Elleaume, Hélène, PhD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c544t-8eeddc654a0a0ec59534fab3a13ca05deb32cf55d8521e5ea841f952a3eb99463</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Animals</topic><topic>Brain - pathology</topic><topic>Brain - radiation effects</topic><topic>Brain - ultrastructure</topic><topic>Brain Neoplasms - diagnostic imaging</topic><topic>Brain Neoplasms - pathology</topic><topic>Brain Neoplasms - radiotherapy</topic><topic>Brain tumors</topic><topic>Cancer</topic><topic>Cell Line, Tumor</topic><topic>Cell Survival - radiation effects</topic><topic>Drug Administration Routes</topic><topic>Glioma</topic><topic>Glioma - diagnostic imaging</topic><topic>Glioma - pathology</topic><topic>Glioma - radiotherapy</topic><topic>Gold - radiation effects</topic><topic>Gold - toxicity</topic><topic>Gold nanoparticles</topic><topic>Internal Medicine</topic><topic>Kaplan-Meier Estimate</topic><topic>Life Sciences</topic><topic>Light</topic><topic>Male</topic><topic>Medical Physics</topic><topic>Metal Nanoparticles - radiation effects</topic><topic>Metal Nanoparticles - toxicity</topic><topic>Neostriatum - drug effects</topic><topic>Neostriatum - pathology</topic><topic>Photoactivation</topic><topic>Physics</topic><topic>Radiography</topic><topic>Rats</topic><topic>Rats, Inbred F344</topic><topic>Subcellular Fractions - metabolism</topic><topic>Subcellular Fractions - radiation effects</topic><topic>Synchrotron radiation</topic><topic>X-Rays</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bobyk, Laure, PhD</creatorcontrib><creatorcontrib>Edouard, Magali, PhD</creatorcontrib><creatorcontrib>Deman, Pierre, PhD</creatorcontrib><creatorcontrib>Vautrin, Mathias, PhD</creatorcontrib><creatorcontrib>Pernet-Gallay, Karin, PhD</creatorcontrib><creatorcontrib>Delaroche, Julie</creatorcontrib><creatorcontrib>Adam, Jean-François, PhD</creatorcontrib><creatorcontrib>Estève, François, MD, PhD</creatorcontrib><creatorcontrib>Ravanat, Jean-Luc, PhD</creatorcontrib><creatorcontrib>Elleaume, Hélène, PhD</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Hyper Article en Ligne (HAL)</collection><jtitle>Nanomedicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bobyk, Laure, PhD</au><au>Edouard, Magali, PhD</au><au>Deman, Pierre, PhD</au><au>Vautrin, Mathias, PhD</au><au>Pernet-Gallay, Karin, PhD</au><au>Delaroche, Julie</au><au>Adam, Jean-François, PhD</au><au>Estève, François, MD, PhD</au><au>Ravanat, Jean-Luc, PhD</au><au>Elleaume, Hélène, PhD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Photoactivation of gold nanoparticles for glioma treatment</atitle><jtitle>Nanomedicine</jtitle><addtitle>Nanomedicine</addtitle><date>2013-10-01</date><risdate>2013</risdate><volume>9</volume><issue>7</issue><spage>1089</spage><epage>1097</epage><pages>1089-1097</pages><issn>1549-9634</issn><eissn>1549-9642</eissn><notes>ObjectType-Article-2</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-1</notes><notes>content type line 23</notes><abstract>Abstract Radiosensitization efficacy of gold nanoparticles (AuNPs) with low energy radiations (88 keV) was evaluated in vitro and in vivo on rats bearing glioma. In vitro, a significant dose-enhancement factor was measured by clonogenic assays after irradiation with synchrotron radiation of F98 glioma cells in presence of AuNPs (1.9 and 15 nm in diameter). In vivo, 1.9 nm nanoparticles were found to be toxic following intracerebral delivery in rats bearing glioma, whether no toxicity was observed using 15 nm nanoparticles at the same concentration (50 mg/mL). The therapeutic efficacy of gold photoactivation was determined by irradiating the animals after intracerebral infusion of AuNPs. Survival of rats that had received the combination of treatments (AuNPs: 50 mg/mL, 15 Gy) was significantly increased in comparison with the survival of rats that had received irradiation alone. In conclusion, this experimental approach is promising and further studies are foreseen for improving its therapeutic efficacy. From the Clinical Editor These investigators report that gold nanoparticles of the correct size can be used to enhance the effects of irradiation in the context of a glioma model. Since many of the glioma varieties are currently incurable, this or similar approaches may find their way to clinical trials in the near future.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>23643529</pmid><doi>10.1016/j.nano.2013.04.007</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-3991-9503</orcidid><orcidid>https://orcid.org/0000-0003-3468-3316</orcidid></addata></record> |
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| subjects | Animals Brain - pathology Brain - radiation effects Brain - ultrastructure Brain Neoplasms - diagnostic imaging Brain Neoplasms - pathology Brain Neoplasms - radiotherapy Brain tumors Cancer Cell Line, Tumor Cell Survival - radiation effects Drug Administration Routes Glioma Glioma - diagnostic imaging Glioma - pathology Glioma - radiotherapy Gold - radiation effects Gold - toxicity Gold nanoparticles Internal Medicine Kaplan-Meier Estimate Life Sciences Light Male Medical Physics Metal Nanoparticles - radiation effects Metal Nanoparticles - toxicity Neostriatum - drug effects Neostriatum - pathology Photoactivation Physics Radiography Rats Rats, Inbred F344 Subcellular Fractions - metabolism Subcellular Fractions - radiation effects Synchrotron radiation X-Rays |
| title | Photoactivation of gold nanoparticles for glioma treatment |
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