Photoactivation of gold nanoparticles for glioma treatment

Abstract Radiosensitization efficacy of gold nanoparticles (AuNPs) with low energy radiations (88 keV) was evaluated in vitro and in vivo on rats bearing glioma. In vitro, a significant dose-enhancement factor was measured by clonogenic assays after irradiation with synchrotron radiation of F98 glio...

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Bibliographic Details
Published in:Nanomedicine 2013-10, Vol.9 (7), p.1089-1097
Main Authors: Bobyk, Laure, PhD, Edouard, Magali, PhD, Deman, Pierre, PhD, Vautrin, Mathias, PhD, Pernet-Gallay, Karin, PhD, Delaroche, Julie, Adam, Jean-François, PhD, Estève, François, MD, PhD, Ravanat, Jean-Luc, PhD, Elleaume, Hélène, PhD
Format: Article
Language:English
Subjects:
Animals
Brain - pathology
Brain - radiation effects
Brain - ultrastructure
Brain Neoplasms - diagnostic imaging
Brain Neoplasms - pathology
Brain Neoplasms - radiotherapy
Brain tumors
Cancer
Cell Line, Tumor
Cell Survival - radiation effects
Drug Administration Routes
Glioma
Glioma - diagnostic imaging
Glioma - pathology
Glioma - radiotherapy
Gold - radiation effects
Gold - toxicity
Gold nanoparticles
Internal Medicine
Kaplan-Meier Estimate
Life Sciences
Light
Male
Medical Physics
Metal Nanoparticles - radiation effects
Metal Nanoparticles - toxicity
Neostriatum - drug effects
Neostriatum - pathology
Photoactivation
Physics
Radiography
Rats
Rats, Inbred F344
Subcellular Fractions - metabolism
Subcellular Fractions - radiation effects
Synchrotron radiation
X-Rays
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Summary:Abstract Radiosensitization efficacy of gold nanoparticles (AuNPs) with low energy radiations (88 keV) was evaluated in vitro and in vivo on rats bearing glioma. In vitro, a significant dose-enhancement factor was measured by clonogenic assays after irradiation with synchrotron radiation of F98 glioma cells in presence of AuNPs (1.9 and 15 nm in diameter). In vivo, 1.9 nm nanoparticles were found to be toxic following intracerebral delivery in rats bearing glioma, whether no toxicity was observed using 15 nm nanoparticles at the same concentration (50 mg/mL). The therapeutic efficacy of gold photoactivation was determined by irradiating the animals after intracerebral infusion of AuNPs. Survival of rats that had received the combination of treatments (AuNPs: 50 mg/mL, 15 Gy) was significantly increased in comparison with the survival of rats that had received irradiation alone. In conclusion, this experimental approach is promising and further studies are foreseen for improving its therapeutic efficacy. From the Clinical Editor These investigators report that gold nanoparticles of the correct size can be used to enhance the effects of irradiation in the context of a glioma model. Since many of the glioma varieties are currently incurable, this or similar approaches may find their way to clinical trials in the near future.
ISSN:1549-9634
1549-9642
DOI:10.1016/j.nano.2013.04.007