A non-steroidal anti-inflammatory drug (ketoprofen) does not delay β-TCP bone graft healing

β-Tricalcium phosphate (β-TCP) is a suitable biomaterial in oral and maxillofacial surgery since it can induce a rapid proliferation of woven bone. Granules, prepared by the polyurethane foam method, were implanted in critical size defects performed in the femoral condyles of New Zealand rabbits. An...

Full description

Saved in:
Bibliographic Details
Published in:Acta biomaterialia 2010-08, Vol.6 (8), p.3310-3317
Main Authors: Nyangoga, Herve, Aguado, Eric, Goyenvalle, Eric, Baslé, Michel Felix, Chappard, Daniel
Format: Article
Language:English
Subjects:
Animals
Anti-Inflammatory Agents, Non-Steroidal - pharmacology
Bioengineering
Biomaterials
Bone graft
Bone healing
Bone Transplantation
Calcium Phosphates - pharmacology
Femur - cytology
Femur - diagnostic imaging
Femur - drug effects
Human health and pathology
Ketoprofen - pharmacology
Life Sciences
MicroCT
Microscopy, Electron, Scanning
Microscopy, Fluorescence
Non-steroidal anti-inflammatory drugs
Rabbits
Rhumatology and musculoskeletal system
Wound Healing - drug effects
X-Ray Microtomography
β-TCP
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:β-Tricalcium phosphate (β-TCP) is a suitable biomaterial in oral and maxillofacial surgery since it can induce a rapid proliferation of woven bone. Granules, prepared by the polyurethane foam method, were implanted in critical size defects performed in the femoral condyles of New Zealand rabbits. Animals were studied after 8 and 28days. Ketoprofen (a non-steroidal anti-inflammatory drug (NSAID)) was given for 8 and 28days to evaluate its effects on the healing of the graft. Before euthanasia, the rabbits received an intravenous injection of fluorescent microbeads. Bones were analyzed by microcomputed tomography. β-TCP granules induced metaplastic bone trabeculae as early as 8days post-surgery. At 28days, the amount of bone was increased and the biomaterial volume decreased due to simultaneous macrophagic resorption. The amount of macrophages labeled with microbeads was less in the grafted area than in the vicinal intact marrow spaces. Ketoprofen had no effect on the amount of bone formed and on the number of labeled macrophages. The influence of small doses of NSAID, given in a short duration period, did not present deleterious effects on bone graft healing.
ISSN:1742-7061
1878-7568
DOI:10.1016/j.actbio.2010.01.042