Pro-inflammatory Phospholipid Arachidonic Acid/Eicosapentaenoic Acid Ratio of Dysmetabolic Severely Obese Women

Background Fatty acids (FAs) and adipokines such as adiponectin or interleukin-6 (IL-6) are known to modulate inflammation and the development of metabolic syndrome. Whether FA composition assessed in plasma triacylglycerols (TAGs), phospholipids (PLs) and non-esterified fatty acids (NEFAs) and adip...

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Bibliographic Details
Published in:Obesity surgery 2012-06, Vol.22 (6), p.935-944
Main Authors: Caspar-Bauguil, S., Fioroni, A., Galinier, A., Allenbach, S., Pujol, M. C., Salvayre, R., Cartier, A., Lemieux, I., Richard, D., Biron, S., Marceau, P., Casteilla, L., Pénicaud, L., Mauriège, P.
Format: Article
Language:English
Subjects:
Adult
Arachidonic Acids
Arachidonic Acids - blood
Chromatography, Gas
Cytokines
Eicosapentaenoic Acid
Eicosapentaenoic Acid - blood
Enzyme-Linked Immunosorbent Assay
Fatty acids
Female
Food and Nutrition
Humans
Interleukin-6
Interleukin-6 - blood
Life Sciences
Medicine
Medicine & Public Health
Metabolic syndrome
Metabolic Syndrome - blood
Metabolic Syndrome - etiology
Metabolic Syndrome X
Obesity
Obesity, Morbid
Obesity, Morbid - blood
Obesity, Morbid - complications
Physiology Research
Real-Time Polymerase Chain Reaction
Subcutaneous Fat, Abdominal
Subcutaneous Fat, Abdominal - metabolism
Surgery
Women
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Summary:Background Fatty acids (FAs) and adipokines such as adiponectin or interleukin-6 (IL-6) are known to modulate inflammation and the development of metabolic syndrome. Whether FA composition assessed in plasma triacylglycerols (TAGs), phospholipids (PLs) and non-esterified fatty acids (NEFAs) and adipose tissue (AT) PLs differed between dysmetabolic and non-dysmetabolic severely obese women remains to be established. Whether the plasma and/or AT arachidonic acid (AA)/eicosapentaenoic acid (EPA) ratio in the PL sub-fraction may be associated with adipokine AT gene expression needs to be examined. Methods FA composition was measured in plasma lipid classes and in the TAG and PL sub-fractions of subcutaneous abdominal and omental ATs of severely obese women paired for age and adiposity but showing a dysmetabolic profile ( n  = 13) or not ( n  = 14). FA profile was assessed by gas chromatography. Plasma and AT mRNA concentrations of adiponectin and IL-6 were measured by ELISA and real-time polymerase chain reaction, respectively. Results Plasma adiponectin and FA concentrations in the NEFA sub-fraction were, respectively, lower and higher in dysmetabolic than in non-dysmetabolic women ( p  
ISSN:0960-8923
1708-0428
DOI:10.1007/s11695-012-0633-0