Self Assembling and Crosslinking of Polyelectrolyte Multilayer Films of Chitosan and Alginate Studied by QCM and IR Spectroscopy

The formation of novel biocompatible multilayer films based on the alternate deposition of CHI and ALG was investigated for the first time by QCM‐D and FTIR‐ATR. A linear increase of the thickness was found during the film build‐up. GLUT was used to crosslink the films terminated with either CHI or...

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Bibliographic Details
Published in:Macromolecular bioscience 2009-08, Vol.9 (8), p.776-785
Main Authors: Alves, Natália M., Picart, Catherine, Mano, João F.
Format: Article
Language:English
Subjects:
Accumulation
Alginates - chemistry
Applied sciences
Assembling
Biocompatible Materials - chemical synthesis
Biocompatible Materials - chemistry
Chitosan
Chitosan - chemistry
Cross-Linking Reagents
Crosslinking
Deposition
Electrochemical Techniques
Evolution
Exact sciences and technology
Glutaral
Infrared radiation
Infrared spectroscopy
layer growth
Multilayers
Natural polymers
Physicochemistry of polymers
polyelectrolytes
Spectroscopy, Fourier Transform Infrared
Starch and polysaccharides
viscoelastic properties
Viscosity
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Summary:The formation of novel biocompatible multilayer films based on the alternate deposition of CHI and ALG was investigated for the first time by QCM‐D and FTIR‐ATR. A linear increase of the thickness was found during the film build‐up. GLUT was used to crosslink the films terminated with either CHI or ALG. A change in the QCM‐D signal was observed just in the first case, indicating that crosslinking only takes place in the top CHI layer. The evolution of the dissipation factor during crosslinking was modelled with a first‐order kinetics; this reaction was found to be faster for chitosan terminated films with a lower number of multilayers. It was also found that more robust films could be produced by crosslinking the intermediate CHI layers during the build‐up. Biodegradable and biocompatible layer‐by‐layer films of chitosan and alginate with controlled properties and thickness, both crosslinked and uncrosslinked, were successfully produced. Quartz crystal microbalance with dissipation monitoring (QCM‐D) was used to follow in real time their build‐up and the crosslinking reactions. The analysis of the formation of the multilayer films was complemented by using FTIR‐ATR.
ISSN:1616-5187
1616-5195
DOI:10.1002/mabi.200800336