Population genetic data on four STR loci, PAI (CA) n , GpIIIa (CT) n , PLAT (TG) 14 (CA) 12, and NOS2A (CCTTT) n , in Mediterranean populations

In the present study, we have analyzed four highly polymorphic regions (STRs) chosen from four candidate genes involved in: (1) Platelet aggregation: alpha subunit of the platelet GpIIb/GpIIIa integrin complex (GpIIIa (CT) n ; 17q21.31), (2) Coagulation fibrinolysis: Plasminogen Activator Tissue (PL...

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Bibliographic Details
Published in:Legal medicine (Tokyo, Japan) Japan), 2007-07, Vol.9 (4), p.218-220
Main Authors: Falchi, Alessandra, Piras, Ignazio Stefano, Giovannoni, Laurianne, Moral, Pedro, Vona, Giuseppe, Varesi, Laurent
Format: Article
Language:English
Subjects:
Africa, Northern
Alleles
Chi-Square Distribution
Data Interpretation, Statistical
European Continental Ancestry Group
European Continental Ancestry Group - genetics
France
Gene Frequency
Genetics
Genetics, Population
Humans
Integrin beta3
Integrin beta3 - genetics
Italy
Life Sciences
Mediterranean
Mediterranean Region
Microsatellite Repeats
Nitric Oxide Synthase Type II
Nitric Oxide Synthase Type II - genetics
Plasminogen Activator Inhibitor 1
Plasminogen Activator Inhibitor 1 - genetics
Polymerase Chain Reaction
Polymorphism, Genetic
Population study
Populations and Evolution
Short tandem repeats
Sicily
Spain
Tissue Plasminogen Activator
Tissue Plasminogen Activator - genetics
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Summary:In the present study, we have analyzed four highly polymorphic regions (STRs) chosen from four candidate genes involved in: (1) Platelet aggregation: alpha subunit of the platelet GpIIb/GpIIIa integrin complex (GpIIIa (CT) n ; 17q21.31), (2) Coagulation fibrinolysis: Plasminogen Activator Tissue (PLAT5 (TG) 14(TA) 12; 8p12-q11.2) and Plasminogen Activator Inhibitor-1 (PAI-1 (CA) n ; 7q21.3-q22), (3) Oxidative metabolism: the inducible nitric oxide (NO) synthase (iNOS) gene (NOS2A (CCTTT) n ; 17cen-q11.2). Allele frequencies for these four STR loci were investigated in several Mediterranean populations. The population data deviate from the Hardy–Weinberg equilibrium in all populations for GpIIIa (CT) n polymorphism.
ISSN:1344-6223
1873-4162
DOI:10.1016/j.legalmed.2007.01.001