Some food-associated mycotoxins as potential risk factors in humans predisposed to chronic intestinal inflammatory diseases

Mycotoxins are fungal metabolites able to affect the functions of numerous tissues and organs in animals and humans, including intestinal and immune systems. However, the potential link between exposure to some mycotoxins and human chronic intestinal inflammatory diseases, such as celiac and Crohn’s...

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Bibliographic Details
Published in:Toxicon (Oxford) 2010-09, Vol.56 (3), p.282-294
Main Authors: Maresca, Marc, Fantini, Jacques
Format: Article
Language:English
Subjects:
Animal poisons toxicology. Antivenoms
Bacterial translocation
Biochemistry
Biochemistry, Molecular Biology
Biological and medical sciences
Chronic Disease
Chronic intestinal inflammatory disease
Disease Susceptibility
Gastroenterology. Liver. Pancreas. Abdomen
Humans
Inflammatory bowel disease
Inflammatory Bowel Diseases
Inflammatory Bowel Diseases - chemically induced
Intestine
Life Sciences
Medical sciences
Mycotoxin
Mycotoxins
Mycotoxins - toxicity
Other diseases. Semiology
Plant poisons toxicology
Risk Factors
Stomach. Duodenum. Small intestine. Colon. Rectum. Anus
Toxicology
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Summary:Mycotoxins are fungal metabolites able to affect the functions of numerous tissues and organs in animals and humans, including intestinal and immune systems. However, the potential link between exposure to some mycotoxins and human chronic intestinal inflammatory diseases, such as celiac and Crohn’s diseases or ulcerative colitis, has not been investigated. Instead, several theories based on bacterial, immunological or neurological events have been elaborated to explain the etiology of these pathologies. Here we reviewed the literature on mycotoxin-induced intestinal dysfunctions and compared these perturbations to the impairments of intestinal functions typically observed in human chronic intestinal inflammatory diseases. Converging evidence based on various cellular and animal studies show that several mycotoxins induce intestinal alterations that are similar to those observed at the onset and during the progression of inflammatory bowel diseases. Although epidemiologic evidence is still required, existing data are sufficient to suspect a role of some food-associated mycotoxins in the induction and/or persistence of human chronic intestinal inflammatory diseases in genetically predisposed patients.
ISSN:0041-0101
1879-3150
0041-0101
DOI:10.1016/j.toxicon.2010.04.016