impact of preoperative breast MRI on the re-excision rate in invasive lobular carcinoma of the breast

Re-excision rates after breast conserving surgery (BCS) of invasive lobular carcinoma (ILC) are high. Preoperative breast MRI has the potential to reduce re-excision rates, but may lead to an increased rate of mastectomies. Hence, we assessed the influence of preoperative breast MRI on the re-excisi...

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Bibliographic Details
Published in:Breast cancer research and treatment 2010-01, Vol.119 (2), p.415-422
Main Authors: Mann, R. M, Loo, C. E, Wobbes, T, Bult, P, Barentsz, J. O, Gilhuijs, K. G. A, Boetes, C
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Biological and medical sciences
Breast cancer
Breast Neoplasms - pathology
Breast Neoplasms - surgery
Cancer
Cancer research
Cancer therapies
Carcinoma
Carcinoma, Lobular - pathology
Carcinoma, Lobular - surgery
Clinical Trial
Clinical trials
Female
Football (College)
Gynecology. Andrology. Obstetrics
Humans
Lumpectomy
Magnetic Resonance Imaging
Mammary gland diseases
Mastectomy
Mastectomy, Segmental
Medical sciences
Medicine
Medicine & Public Health
Middle Aged
Neoplasm Invasiveness
Netherlands
NMR
Nuclear magnetic resonance
Odds Ratio
Oncology
Predictive Value of Tests
Preoperative Care
Reoperation
Retrospective Studies
Risk Assessment
Time Factors
Treatment Outcome
Tumors
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Summary:Re-excision rates after breast conserving surgery (BCS) of invasive lobular carcinoma (ILC) are high. Preoperative breast MRI has the potential to reduce re-excision rates, but may lead to an increased rate of mastectomies. Hence, we assessed the influence of preoperative breast MRI on the re-excision rate and the rate of mastectomies. We performed a retrospective cohort study of a consecutive series of patients with ILC who presented in one of two dedicated tertiary cancer centers between 1993 and 2005. We assessed the initial type of surgery (BCS or mastectomy), the re-excision rate and the final type of surgery. Patients were stratified into two groups: those who received preoperative MRI (MR+ group) and those who did not (MR− group). In the MR− group, 27% of the patients underwent a re-excision after initial BCS. In the MR+ group, this rate was significantly lower at 9%. The odds ratio was 3.64 (95% CI: 1.30-10.20, P = 0.010). There was a trend towards a lower final mastectomy rate in the MR+ group compared to the MR− group (48 vs. 59%, P = 0.098). In conclusion, preoperative MRI in patients with ILC can reduce re-excision rates without increasing the rate of mastectomies.
ISSN:0167-6806
1573-7217
DOI:10.1007/s10549-009-0616-6