Novel biological and possible applicable roles of LH/hCG receptor

Luteinizing hormone/human chorionic gonadotropin (LH/hCG) receptors are widely expressed in gonadal cells, however, the presence of these receptors has also been demonstrated in several other non-gonadal female and male tissues. The expression level of non-gonadal LH/hCG receptors is much lower than...

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Bibliographic Details
Published in:Molecular and cellular endocrinology 2007-04, Vol.269 (1), p.51-60
Main Authors: Ziecik, Adam J., Kaczmarek, Monika M., Blitek, Agnieszka, Kowalczyk, Anna E., Li, Xiangdong, Rahman, Nafis A.
Format: Article
Language:English
Subjects:
Animals
Cancer
Chorionic Gonadotropin - therapeutic use
Endometrium - metabolism
Fallopian Tubes - metabolism
Female
Gene Expression Regulation
Humans
LH/hCG receptor
Luteinizing Hormone - therapeutic use
Models, Biological
Myometrium - metabolism
Neoplasms - drug therapy
Oviduct
Receptors, LH - genetics
Receptors, LH - metabolism
Receptors, LH - physiology
Uterus
Uterus - blood supply
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Summary:Luteinizing hormone/human chorionic gonadotropin (LH/hCG) receptors are widely expressed in gonadal cells, however, the presence of these receptors has also been demonstrated in several other non-gonadal female and male tissues. The expression level of non-gonadal LH/hCG receptors is much lower than in gonads, although their expression is regulated by similar mechanisms and they also exert biological effects using similar signaling pathways. Hormonally regulated LH/hCG receptor expression in the oviduct suggests that LH could be involved in the regulation of its contraction, gametes/embryos transport and synchronization of the fertilization. One of the major roles of the myometrial LH/hCG receptors may also be the stimulation of growth and maintenance of the uterine relaxation during pregnancy. In pigs, LH seems to be one of the pleiotropic factors which influence the endometrial prostaglandin F 2α synthesis and initiation of the luteolysis. The LH/hCG receptor expression in several cancer cells provides new possibilities for developing new strategies for targeted cancer therapy based on lytic LH/hCG conjugates.
ISSN:0303-7207
1872-8057
0303-7207
DOI:10.1016/j.mce.2006.08.016