Initiation of pre-B cell receptor signaling: Common and distinctive features in human and mouse

B cell development in the bone marrow is a highly regulated process and expression of a functional pre-BCR represents a crucial checkpoint, common to human and mouse. In this review, we discuss pre-BCR analogies and differences between the two species leading to pre-B cell differentiation and prolif...

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Bibliographic Details
Published in:Seminars in Immunology 2006-02, Vol.18 (1), p.56-66
Main Authors: Espeli, Marion, Rossi, Benjamin, Mancini, Stéphane J.C., Roche, Philippe, Gauthier, Laurent, Schiff, Claudine
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Animals
B-Lymphocytes
B-Lymphocytes - cytology
B-Lymphocytes - metabolism
B-Lymphocytes - physiology
Biochemistry, Molecular Biology
Bone marrow
Cell Differentiation
Cell Differentiation - physiology
Galectin
Heparan sulfate
Humans
Life Sciences
Membrane Glycoproteins
Membrane Glycoproteins - physiology
Mice
Molecular Sequence Data
Pre-B Cell Receptors
Pre-BCR
Receptors, Antigen, B-Cell
Signal Transduction
Signal Transduction - physiology
Stroma
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Summary:B cell development in the bone marrow is a highly regulated process and expression of a functional pre-BCR represents a crucial checkpoint, common to human and mouse. In this review, we discuss pre-BCR analogies and differences between the two species leading to pre-B cell differentiation and proliferation. In addition, the mechanisms triggering pre-BCR activation are reviewed, taking into account the recent report of heparan sulfates and galectin 1 as stromal cell-derived pre-BCR ligands. Finally, ligand-induced pre-BCR activation models are proposed on the bases of the differences reported for pre-BCR and IL7 dependencies in the two species.
ISSN:1044-5323
1096-3618
1365-2567
DOI:10.1016/j.smim.2005.11.002