Low lactase activity in a small-bowel biopsy specimen: Should dietary lactose intake be restricted in children with small intestinal mucosal damage?

Objective. Small intestinal mucosal damage can result in decreased lactase activity (LA). When LA is low in a small-bowel biopsy (SBB) specimen, a reduction of dietary lactose intake is usually advised. This is often done by reducing dietary dairy products, which also reduces the intake of calcium,...

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Bibliographic Details
Published in:Scandinavian journal of gastroenterology 2006, Vol.41 (1), p.37-41
Main Authors: Koetse, Harma A., Vonk, Roel J., Gonera-De Jong, Gieneke B. C., Priebe, Marion G., Antoine, Jean-M, Stellaard, Frans, Sauer, Pieter J. J.
Format: Article
Language:English
Subjects:
Biological and medical sciences
Biopsy
Child
Child, Preschool
Children
Diseases of the digestive system
domain_sdv.ida.ing
domain_sdv.ida.ing.ing
Female
Food engineering
Gastroenterology. Liver. Pancreas. Abdomen
Humans
in vivo lactose digestion index
Infant
Intestinal Mucosa - enzymology
Intestinal Mucosa - pathology
Intestine, Small - enzymology
Intestine, Small - pathology
Lactase - metabolism
lactase activity
Lactose - administration & dosage
lactose digestion
Lactose Intolerance - diagnosis
Lactose Tolerance Test
Life Sciences
Male
Medical sciences
mucosal damage
Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)
small intestinal function
small-bowel biopsy
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Summary:Objective. Small intestinal mucosal damage can result in decreased lactase activity (LA). When LA is low in a small-bowel biopsy (SBB) specimen, a reduction of dietary lactose intake is usually advised. This is often done by reducing dietary dairy products, which also reduces the intake of calcium, protein and vitamins. Since intestinal damage can have a patchy character and LA varies along the horizontal axis of the small intestine, the relevance of SBB measurement for intestinal LA could be questioned. We compared LA in the SBB with the in vivo capacity to digest lactose using the Lactose Digestion Index (LDI). Material and methods. LA was measured in 18 children aged 0.8-10.9 years (mean 3.9, SD 2.4) undergoing SBB for various indications. In all children the LDI was determined using the 13C-lactose/2H-glucose test. Results. In 9/18 biopsy specimens LA was low (
ISSN:0036-5521
1502-7708
DOI:10.1080/00365520510023981